1. Gene
  2. DDIT4 - DNA damage inducible transcript 4 Gene

DDIT4 - DNA damage inducible transcript 4 Gene

Homo sapiens

Also known as Dig2; REDD1; REDD-1

Gene ID: 54541 | Gene type: protein coding

About DDIT4

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,273,924-72,276,036 (from NCBI)

This gene has 5 transcripts (splice variants), 257 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 89.7), fat (RPKM 84.2) and 25 other tissues.

Summary

Predicted to enable 14-3-3 protein binding activity. Involved in defense response to virus; negative regulation of TOR signaling; and response to hypoxia. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

DDIT4 Products(1)

mRNA Protein Name
NM_019058.4 NP_061931.1 DNA damage-inducible transcript 4 protein

DDIT4 Protein Structure

RTP801_C

RTP801_C: RTP801 C-terminal region (104 - 223)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

DNA damage-inducible transcript 4 protein

HIF-1 responsive protein RTP801

DDIT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DDIT4 Q9NX09 MTF2 Homo sapiens Q9Y483-4 32814053
Intra
DDIT4 Q9NX09 MTF2 Homo sapiens Q9Y483-4 32814053
Intra
DDIT4 Q9NX09 MTF2 Homo sapiens Q9Y483-4 32814053
Intra
DDIT4 Q9NX09 SLC3A2 Homo sapiens P08195-4 32814053
Intra
DDIT4 Q9NX09 SLC3A2 Homo sapiens P08195-4 32814053
Intra
DDIT4 Q9NX09 SLC3A2 Homo sapiens P08195-4 32814053
Intra
DDIT4 Q9NX09 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DDIT4 Q9NX09 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DDIT4 Q9NX09 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DDIT4 Q9NX09 FOXD4L6 Homo sapiens Q3SYB3 32814053
Intra
DDIT4 Q9NX09 FOXD4L6 Homo sapiens Q3SYB3 32814053
Intra
DDIT4 Q9NX09 FOXD4L6 Homo sapiens Q3SYB3 32814053
Intra
DDIT4 Q9NX09 VSX2 Homo sapiens P58304 32814053
Intra
DDIT4 Q9NX09 VSX2 Homo sapiens P58304 32814053
Intra
DDIT4 Q9NX09 VSX2 Homo sapiens P58304 32814053
Intra
DDIT4 Q9NX09 PECAM1 Homo sapiens P16284 32814053
Intra
DDIT4 Q9NX09 PECAM1 Homo sapiens P16284 32814053
Intra
DDIT4 Q9NX09 PECAM1 Homo sapiens P16284 32814053
Intra
DDIT4 Q9NX09 KEAP1 Homo sapiens Q14145 32814053
Intra
DDIT4 Q9NX09 KEAP1 Homo sapiens Q14145 32814053
Intra
DDIT4 Q9NX09 KEAP1 Homo sapiens Q14145 32814053
Intra
DDIT4 Q9NX09 KLF3 Homo sapiens P57682 32814053
Intra
DDIT4 Q9NX09 KLF3 Homo sapiens P57682 32814053
Intra
DDIT4 Q9NX09 KLF3 Homo sapiens P57682 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Atrophy

Atrophic Condition Of Skin

Atrophoderma

Atrophy - Skin

Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Familial Hyperinsulinemic Hypoglycemia 1

Congenital Hyperinsulinism

Phhi

Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Of Infancy

Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

Nesidioblastosis Of Pancreas

Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis

Hyperinsulinism, Congenital

Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency

Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form

Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency

Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus DDIT4 VGNC VGNC:61390
Canis familiaris DDIT4 VGNC VGNC:39837
Mus musculus DDIT4 MGD MGI:1921997
Bos taurus DDIT4 VGNC VGNC:27948
Rattus norvegicus DDIT4 RGD RGD:621731