KLF3 - KLF transcription factor 3 Gene

Homo sapiens

Also known as BKLF

Gene ID: 51274 | Gene type: protein coding

About KLF3

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:38,664,199-38,701,517 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 22 paralogues. Ubiquitous expression in colon (RPKM 22.1), gall bladder (RPKM 19.2) and 25 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

KLF3 Products(1)

mRNA	Protein	Name
NM_016531.6	NP_057615.3	Krueppel-like factor 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF3 Protein Structure

zf-H2C2_2

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

Krueppel-like factor 3

CACCC-box-binding protein BKLF

KLF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLF3	P57682	CTBP1	Homo sapiens	Q13363-2	BFG-2H	27107012
Intra	KLF3	P57682	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	KLF3	P57682	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	KLF3	P57682	EHMT2	Homo sapiens	A2ABF9	Y2H Prey Pooling	25416956
Intra	KLF3	P57682	LHX6	Homo sapiens	Q9UPM6	Y2H Array	32296183
Intra	KLF3	P57682	LHX6	Homo sapiens	Q9UPM6	Y2H Prey Pooling	32296183
Intra	KLF3	P57682	LHX6	Homo sapiens	Q9UPM6	Validated Y2H	32296183
Intra	KLF3	P57682	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	KLF3	P57682	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	KLF3	P57682	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	KLF3	P57682	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	KLF3	P57682	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	KLF3	P57682	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	KLF3	P57682	BACE2	Homo sapiens	Q9Y5Z0	Y2H Array	32814053
Intra	KLF3	P57682	BACE2	Homo sapiens	Q9Y5Z0	Validated Y2H	32814053
Intra	KLF3	P57682	BACE2	Homo sapiens	Q9Y5Z0	Y2H Pooling	32814053
Intra	KLF3	P57682	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	KLF3	P57682	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	KLF3	P57682	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	KLF3	P57682	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	KLF3	P57682	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	KLF3	P57682	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	KLF3	P57682	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	KLF3	P57682	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	KLF3	P57682	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	KLF3	P57682	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	KLF3	P57682	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	KLF3	P57682	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	KLF3	P57682	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	KLF3	P57682	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	KLF3	P57682	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	KLF3	P57682	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	KLF3	P57682	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	KLF3	P57682	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	KLF3	P57682	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	KLF3	P57682	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	KLF3	P57682	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	KLF3	P57682	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	KLF3	P57682	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	KLF3	P57682	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	KLF3	P57682	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	KLF3	P57682	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	KLF3	P57682	LRIF1	Homo sapiens	Q5T3J3	Validated Y2H	32814053
Intra	KLF3	P57682	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32814053
Intra	KLF3	P57682	LRIF1	Homo sapiens	Q5T3J3	Y2H Pooling	32814053
Intra	KLF3	P57682	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	KLF3	P57682	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	KLF3	P57682	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	KLF3	P57682	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KLF3	P57682	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KLF3	P57682	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KLF3	P57682	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	25416956
Intra	KLF3	P57682	DVL3	Homo sapiens	Q92997	Validated Y2H	25416956
Intra	KLF3	P57682	DVL3	Homo sapiens	Q92997	Y2H Array	25416956
Intra	KLF3	P57682	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	KLF3	P57682	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	KLF3	P57682	FHL3	Homo sapiens	Q13643	MAPPIT	25416956
Intra	KLF3	P57682	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	KLF3	P57682	EHMT2	Homo sapiens	Q96KQ7	Y2H Array	32296183
Intra	KLF3	P57682	EHMT2	Homo sapiens	Q96KQ7	Y2H Prey Pooling	32296183
Intra	KLF3	P57682	EHMT2	Homo sapiens	Q96KQ7	BioID	35140242
Intra	KLF3	P57682	EHMT2	Homo sapiens	Q96KQ7	Validated Y2H	32296183
Intra	KLF3	P57682	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	KLF3	P57682	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	KLF3	P57682	GRN	Homo sapiens	P28799	BioID	35140242
Intra	KLF3	P57682	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	KLF3	P57682	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	KLF3	P57682	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	KLF3	P57682	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	KLF3	P57682	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Array	32814053
Intra	KLF3	P57682	KCNIP3	Homo sapiens	Q9Y2W7	Y2H Pooling	32814053
Intra	KLF3	P57682	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32814053
Intra	KLF3	P57682	LHX8	Homo sapiens	Q68G74	Y2H Prey Pooling	25416956
Intra	KLF3	P57682	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	KLF3	P57682	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	KLF3	P57682	ATXN1	Homo sapiens	P54253	BioID	35140242
Intra	KLF3	P57682	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
Intra	KLF3	P57682	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	KLF3	P57682	PEX1	Homo sapiens	O43933	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cutaneous Adenocystic Carcinoma

Adenoid Cystic Eccrine Carcinoma	Adenoid Cystic Carcinoma Of The Skin
Adenoid Cystic Eccrine Carcinoma Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07340	KLF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KLF3	VGNC	VGNC:73840
Rattus norvegicus	KLF3	RGD	RGD:1593290
Felis catus	KLF3	VGNC	VGNC:63134
Canis familiaris	KLF3	VGNC	VGNC:42436
Mus musculus	KLF3	MGD	MGI:1342773
Bos taurus	KLF3	VGNC	VGNC:30630

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