BCAS3 - BCAS3 microtubule associated cell migration factor Gene

Homo sapiens

Also known as MAAB; GAOB1; PHAF2; HEMARS

Gene ID: 54828 | Gene type: protein coding

About BCAS3

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:60,677,851-61,392,831 (from NCBI)

This gene has 34 transcripts (splice variants), 212 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 4.9), brain (RPKM 4.0) and 25 other tissues.

Summary

Enables several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and Histone Acetyltransferase binding activity. Involved in cellular response to estrogen stimulus; positive regulation of catalytic activity; and positive regulation of transcription by RNA polymerase II. Located in nucleus; phagophore assembly site; and transcriptionally active chromatin. Biomarker of breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

BCAS3 Products(8)

mRNA	Protein	Name
NM_001099432.3	NP_001092902.1	BCAS3 microtubule associated cell migration factor isoform 1
NM_001320470.3	NP_001307399.1	BCAS3 microtubule associated cell migration factor isoform 3
NM_001330413.2	NP_001317342.1	BCAS3 microtubule associated cell migration factor isoform 4
NM_001330414.2	NP_001317343.1	BCAS3 microtubule associated cell migration factor isoform 5
NM_001353144.2	NP_001340073.1	BCAS3 microtubule associated cell migration factor isoform 6
NM_001353145.2	NP_001340074.1	BCAS3 microtubule associated cell migration factor isoform 7
NM_001353146.2	NP_001340075.1	BCAS3 microtubule associated cell migration factor isoform 8
NM_017679.5	NP_060149.3	BCAS3 microtubule associated cell migration factor isoform 2

BCAS3 Protein Structure

WD40

BCAS3

0
200
400
600
800
928 a.a.

Protein Preferred Names

Protein Names

BCAS3 microtubule associated cell migration factor

BCAS4/BCAS3 fusion

Related Diseases

Diseases

Alias

Hengel-Maroofian-Schols Syndrome

HEMARS

Neurodevelopmental Disorder With Spasticity, Facial Dysmorphism, And Brain Abnormalities

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01401	BCAS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BCAS3	MGD	MGI:2385848
Bos taurus	BCAS3	VGNC	VGNC:26438
Macaca mulatta	BCAS3	VGNC	VGNC:70073
Felis catus	BCAS3	VGNC	VGNC:60080
Rattus norvegicus	BCAS3	RGD	RGD:1560788
Canis familiaris	BCAS3	VGNC	VGNC:38400

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