FNBP1L - formin binding protein 1 like Gene

Homo sapiens

Also known as TOCA1; C1orf39

Gene ID: 54874 | Gene type: protein coding

About FNBP1L

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,448,118-93,554,661 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 14.8), kidney (RPKM 13.9) and 24 other tissues.

Summary

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin Cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

FNBP1L Products(3)

mRNA	Protein	Name
NM_001024948.3	NP_001020119.1	formin-binding protein 1-like isoform 1
NM_001164473.3	NP_001157945.1	formin-binding protein 1-like isoform 3
NM_017737.5	NP_060207.2	formin-binding protein 1-like isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	19798448	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16630611	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	22684256	GOA
involved in clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	20730103	GOA
involved in membrane invagination	IDA IDA: Inferred from direct assay	20730103	GOA
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	20730103	GOA
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	20730103	GOA
involved in vesicle budding from membrane	IDA IDA: Inferred from direct assay	20730103	GOA
involved in vesicle organization	IDA IDA: Inferred from direct assay	20730103	GOA
involved in vesicle transport along actin filament	IDA IDA: Inferred from direct assay	20730103	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22684256	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	20730103	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FNBP1L Protein Structure

FCH

SH3_1

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

formin-binding protein 1-like

toca-1

FNBP1L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FNBP1L	Q5T0N5	FNBP1	Homo sapiens	Q96RU3	Anti Tag CoIP	35271311
Intra	FNBP1L	Q5T0N5	DAAM1	Homo sapiens	Q9Y4D1	Anti Bait CoIP	16630611
Intra	FNBP1L	Q5T0N5	DAAM1	Homo sapiens	Q9Y4D1	Pull Down	16630611

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease 11

Ad11	Alzheimer'S Disease 11
Alzheimer Disease, Familial, 11	Alzheimer Disease-11
Alzheimer'S Disease 11, Late Onset

Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05017	FNBP1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FNBP1L	MGD	MGI:1925642
Canis familiaris	FNBP1L	VGNC	VGNC:40925
Bos taurus	FNBP1L	VGNC	VGNC:29060
Rattus norvegicus	FNBP1L	RGD	RGD:1305386
Macaca mulatta	FNBP1L	VGNC	VGNC:72543
Felis catus	FNBP1L	VGNC	VGNC:62317

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