DAAM1 - dishevelled associated activator of morphogenesis 1 Gene

Homo sapiens

Gene ID: 23002 | Gene type: protein coding

About DAAM1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,188,667-59,371,405 (from NCBI)

This gene has 13 transcripts (splice variants), 238 orthologues and 18 paralogues. Ubiquitous expression in skin (RPKM 17.9), esophagus (RPKM 12.9) and 25 other tissues.

Summary

Cell motility, adhesion, cytokinesis, and Other functions of the cell cortex are mediated by reorganization of the actin Cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

DAAM1 Products(2)

mRNA	Protein	Name
NM_001270520.2	NP_001257449.1	disheveled-associated activator of morphogenesis 1 isoform 2
NM_014992.2	NP_055807.1	disheveled-associated activator of morphogenesis 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16630611	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16630611	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	26644512	GOA
located in motile cilium	IDA IDA: Inferred from direct assay	26644512	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	20534871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAAM1 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1000
1078 a.a.

Protein Preferred Names

Protein Names

disheveled-associated activator of morphogenesis 1

DAAM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DAAM1	Q9Y4D1	INTU	Homo sapiens	Q9ULD6	Anti Tag CoIP	26644512
Intra	DAAM1	Q9Y4D1	DAAM1	Homo sapiens	Q9Y4D1	Pull Down	18218625
Intra	DAAM1	Q9Y4D1	RHOC	Homo sapiens	P08134	Pull Down	18218625
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	Anti Bait CoIP	18218625
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	Pull Down	18218625
Intra	DAAM1	Q9Y4D1	DAAM1	Homo sapiens	Q9Y4D1	Pull Down	16630611
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	PLA	25241761
Intra	DAAM1	Q9Y4D1	TRIP10	Homo sapiens	Q15642-2	Anti Tag CoIP	16630611
Intra	DAAM1	Q9Y4D1	TRIP10	Homo sapiens	Q15642-2	Pull Down	16630611
Intra	DAAM1	Q9Y4D1	RHOA	Homo sapiens	P61586	SPR	18218625
Cross	DAAM1	Q9Y4D1	SRC	Gallus gallus	P00523	Pull Down	16630611
Cross	DAAM1	Q9Y4D1	SRC	Gallus gallus	P00523	Anti Bait CoIP	16630611

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish	Fdd
Familial Danish Dementia	Heredopathia Ophthalmootoencephalica
Hooe	Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis
Adan Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy 2
Itm2b Amyloidosis	Familial Cerebral Amyloid Angiopathy
Itm2b-Related Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy
Familial Dementia, Danish Type	Cerebral Amyloid Angiopathy, Itm2b-Related 2
CAA-ITM2B2	Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis
Dementia, Familial, Danish

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect	Taussig-Bing Syndrome
Dextrotransposition Of Aorta	Taussig-Bing Syndrome Or Defect
Dorv	Dorv With Subpulmonary Vsd
Dorv-Tga	Double Outlet Right Ventricle With Transposition Of The Great Arteries
Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type	Taussig-Bing Heart
Taussig-Bing Malformation	Taussig-Bing Complex
Taussig-Bing Defect	Taussig-Bing
Double Outlet Right Ventricle With Remote Ventricular Septal Defect	Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect
Double Outlet Right Ventricle With Non-Committed Interventricular Communication	Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis
Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03508	DAAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DAAM1	VGNC	VGNC:27862
Macaca mulatta	DAAM1	VGNC	VGNC:71657
Canis familiaris	DAAM1	VGNC	VGNC:39756
Mus musculus	DAAM1	MGD	MGI:1914596
Felis catus	DAAM1	VGNC	VGNC:61326
Rattus norvegicus	DAAM1	RGD	RGD:1305119

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