ALKBH5 - alkB homolog 5, RNA demethylase Gene

Homo sapiens

Also known as ABH5; OFOXD; OFOXD1

Gene ID: 54890 | Gene type: protein coding

About ALKBH5

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,183,828-18,209,954 (from NCBI)

This gene has 3 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 46.1), heart (RPKM 30.6) and 25 other tissues.

Summary

Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

ALKBH5 Products(1)

mRNA	Protein	Name
NM_017758.4	NP_060228.3	RNA demethylase ALKBH5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2-oxoglutarate-dependent dioxygenase activity	IDA IDA: Inferred from direct assay	21264265	GOA
enables mRNA N6-methyladenosine dioxygenase activity	IDA IDA: Inferred from direct assay	23177736	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	37474102	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA destabilization	IDA IDA: Inferred from direct assay	34048572	GOA
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	37474102	GOA
acts upstream of or within regulation of mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	23177736	GOA
acts upstream of or within regulation of mRNA processing	IMP IMP: Inferred from mutant phenotype	23177736	GOA
involved in regulation of translation	IDA IDA: Inferred from direct assay	36944332	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	21264265	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	23177736	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21264265	GOA
is active in paraspeckles	IDA IDA: Inferred from direct assay	37474102	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH5 Protein Structure

2OG-FeII_Oxy_2

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

RNA demethylase ALKBH5

AlkB family member 5, RNA demethylase

ALKBH5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83693	ALKBH5 Antibody (YA3429)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Cervix Carcinoma

Cancer Of Cervix	Carcinoma Of Cervix
Carcinoma Cervix Uteri	Carcinoma Of The Cervix Uteri

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12304	IOX1	Inhibitor	99.72%	Unkown
HY-155489	DDO-2728		98.55%	Unkown
HY-148933	ALKBH5-IN-2		/	Unkown
HY-RS00606	ALKBH5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-165422	ALKBH5-IN-3	Inhibitor	99.49%	Unkown
HY-170668	DDO-02267	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALKBH5	RGD	RGD:1309496
Macaca mulatta	ALKBH5	VGNC	VGNC:103786
Bos taurus	ALKBH5	VGNC	VGNC:25836
Canis familiaris	ALKBH5	VGNC	VGNC:53262
Felis catus	ALKBH5	VGNC	VGNC:98758
Mus musculus	ALKBH5	MGD	MGI:2144489

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