TESC - tescalcin Gene

Homo sapiens

Also known as TSC; CHP3

Gene ID: 54997 | Gene type: protein coding

About TESC

Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:117,038,923-117,099,416 (from NCBI)

This gene has 8 transcripts (splice variants), 288 orthologues and 8 paralogues. Broad expression in salivary gland (RPKM 66.0), stomach (RPKM 63.6) and 14 other tissues.

Summary

Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TESC Products(2)

mRNA	Protein	Name
NM_001168325.2	NP_001161797.1	calcineurin B homologous protein 3 isoform 2
NM_017899.4	NP_060369.3	calcineurin B homologous protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	11696366	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11696366	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to retinoic acid	IDA IDA: Inferred from direct assay	20060826	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of granulocyte differentiation	IDA IDA: Inferred from direct assay	20060826	GOA
involved in positive regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	18321853	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18321853	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	18321853	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18321853	GOA
involved in regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	17717601	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18321853	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11696366	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17717601	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18321853	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TESC Protein Structure

EF-hand_6

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

calcineurin B homologous protein 3

calcineurin-like EF hand protein 3

TESC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TESC	Q96BS2	WBP11	Homo sapiens	Q9Y2W2	Validated Y2H	25416956
Intra	TESC	Q96BS2	WBP11	Homo sapiens	Q9Y2W2	Y2H Prey Pooling	25416956
Intra	TESC	Q96BS2	HMG20A	Homo sapiens	Q9NP66	Pull Down	16189514
Intra	TESC	Q96BS2	SLC9A1	Homo sapiens	P19634	Fluorescence	31912575

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14379	TESC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TESC	VGNC	VGNC:35753
Canis familiaris	TESC	VGNC	VGNC:52973
Macaca mulatta	TESC	VGNC	VGNC:79571
Felis catus	TESC	VGNC	VGNC:66088
Mus musculus	TESC	MGD	MGI:1930803
Rattus norvegicus	TESC	RGD	RGD:1566317

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