TESC - tescalcin Gene

Homo sapiens

Also known as TSC; CHP3

Gene ID: 54997 | Gene type: protein coding

About TESC

Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:117,038,923-117,099,416 (from NCBI)

This gene has 8 transcripts (splice variants), 288 orthologues and 8 paralogues. Broad expression in salivary gland (RPKM 66.0), stomach (RPKM 63.6) and 14 other tissues.

Summary

Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TESC Products(2)

mRNA	Protein	Name
NM_001168325.2	NP_001161797.1	calcineurin B homologous protein 3 isoform 2
NM_017899.4	NP_060369.3	calcineurin B homologous protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	11696366	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11696366	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to retinoic acid	IDA IDA: Inferred from direct assay	20060826	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of granulocyte differentiation	IDA IDA: Inferred from direct assay	20060826	GOA
involved in positive regulation of megakaryocyte differentiation	IMP IMP: Inferred from mutant phenotype	17717601	GOA
involved in positive regulation of sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	18321853	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18321853	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	18321853	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18321853	GOA
involved in regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	17717601	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18321853	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	11696366	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17717601	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18321853	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TESC Protein Structure

EF-hand_6

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

calcineurin B homologous protein 3

calcineurin-like EF hand protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14379	TESC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TESC	VGNC	VGNC:35753
Canis familiaris	TESC	VGNC	VGNC:52973
Macaca mulatta	TESC	VGNC	VGNC:79571
Felis catus	TESC	VGNC	VGNC:66088
Mus musculus	TESC	MGD	MGI:1930803
Rattus norvegicus	TESC	RGD	RGD:1566317

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