2. Gene
  3. WBP11 - WW domain binding protein 11 Gene

WBP11 - WW domain binding protein 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BUG13; FAP90; NPWBP; SIPP1; VCTRL; CFAP90; VCTERL; WBP-11; PPP1R165

Gene ID: 51729 | Gene type: protein coding

About WBP11

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:14,784,582-14,803,478 (from NCBI)

This gene has 5 transcripts (splice variants), 17 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 48.6), bone marrow (RPKM 38.2) and 25 other tissues.

Summary

This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

WBP11 Products(1)

mRNA Protein Name
NM_016312.3 NP_057396.1 WW domain-binding protein 11
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
19592703 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16000308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WBP11 Protein Structure

Wbp11

Wbp11: WW domain binding protein 11 (12 - 93)

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  • 641 a.a.
Protein Preferred Names Protein Names

WW domain-binding protein 11

Npw38-binding protein NpwBP

WBP11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra WBP11 Q9Y2W2 MCRS1 Homo sapiens Q96EZ8
MAPPIT
32296183
Intra WBP11 Q9Y2W2 PPP1CA Homo sapiens P62136
Y2H
22321011
Intra WBP11 Q9Y2W2 PPP1CA Homo sapiens P62136
Y2H
22365833
Intra WBP11 Q9Y2W2 TRAF4 Homo sapiens Q9BUZ4
Y2H Array
25416956
Intra WBP11 Q9Y2W2 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
25416956
Intra WBP11 Q9Y2W2 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
25416956
Intra WBP11 Q9Y2W2 GRB2 Homo sapiens P62993
Validated Y2H
25416956
Intra WBP11 Q9Y2W2 GRB2 Homo sapiens P62993
Y2H Array
25416956
Intra WBP11 Q9Y2W2 FYN Homo sapiens P06241
Validated Y2H
25416956
Intra WBP11 Q9Y2W2 FYN Homo sapiens P06241
Y2H Array
25416956
Intra WBP11 Q9Y2W2 PQBP1 Homo sapiens O60828
MAPPIT
25416956
Intra WBP11 Q9Y2W2 PQBP1 Homo sapiens O60828
Anti Tag CoIP
25416956
Intra WBP11 Q9Y2W2 PQBP1 Homo sapiens O60828
Anti Tag CoIP
33961781
Intra WBP11 Q9Y2W2 TESC Homo sapiens Q96BS2
Y2H Array
25416956
Intra WBP11 Q9Y2W2 C5orf22 Homo sapiens Q49AR2
Anti Tag CoIP
33961781
Intra WBP11 Q9Y2W2 C5orf22 Homo sapiens Q49AR2
Anti Tag CoIP
28514442
Intra WBP11 Q9Y2W2 C5orf22 Homo sapiens Q49AR2
Y2H Pooling
16189514
Intra WBP11 Q9Y2W2 CD2BP2 Homo sapiens O95400
Y2H
16000308
Intra WBP11 Q9Y2W2 CD2BP2 Homo sapiens O95400
Protein Array
16000308
Cross WBP11 Q9Y2W2 Q99IB8-PRO_0000045603 Hepatitis C virus Q99IB8-PRO_0000045603
Y2H
24136289
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects

VCTERL

Vcterl Syndrome

VCTRL
Baastrup'S Syndrome

Kissing Spine

Baastrup Syndrome

Kissing Spine, Site Unspecified

Osteoarthrosis Interspinalis

Overriding Of Dorsal Spinous Processes

Localised Idiopathic Skeletal Hyperostosis

Baastrup Disease
Renpenning Syndrome 1

Renpenning Syndrome

Golabi-Ito-Hall Syndrome

Mrxs3

Mrxs8

X-Linked Intellectual Disability Due To Pqbp1 Mutations

RENS1

Sutherland-Haan X-Linked Mental Retardation Syndrome

Shs

Mrx55

X-Linked Intellectual Disability, Renpenning Type

Sutherland-Haan Syndrome

Mental Retardation, X-Linked, Renpenning Type

Mental Retardation, X-Linked, With Spastic Diplegia

Mental Retardation, X-Linked, Syndromic 3

Mental Retardation, X-Linked, Syndromic 8

Mental Retardation, X-Linked 55

Syndromic X-Linked Mental Retardation 8

X-Linked Mental Retardation Renpenning Type

X-Linked Mental Retardation With Spastic Diplegia

Sutherland-Haan X-Linked Intellectual Disability Syndrome

X-Linked Intellectual Disability With Spastic Diplegia

Hamel Cerebropalatocardiac Syndrome

Porteous Syndrome

X-Linked Intellectual Deficit Due To Pqbp1 Mutations

X-Linked Intellectual Deficit, Renpenning Type

X-Linked Intellectual Disability, Sutherland-Haan Type

Hamel Cerebro-Palato-Cardiac Syndrome

Renpenning Syndrome, Type 1
Olmsted Syndrome, X-Linked

OLMSX

Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked

Ppkmx

X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

X-Linked Olmsted Syndrome

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

Abdominal Obesity-Metabolic Syndrome

Abdominal Obesity Metabolic Syndrome

Metabolic Syndrome X

Aoms2

Aoms1
Syndromic X-Linked Intellectual Disability

X-Linked Syndromic Intellectual Disability
Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2

FANCD2

Fad2

Fa4

Fancd

Fanconi Pancytopenia Type 4

Fanconi Anemia, Complementation Group D

Fanconi Pancytopenia, Type 4

Facd

Fanconi Anemia Complementation Group D
Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15749 WBP11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta WBP11 VGNC VGNC:99700
Canis familiaris WBP11 VGNC VGNC:48339
Rattus norvegicus WBP11 RGD RGD:1307911
Mus musculus WBP11 MGD MGI:1891823