HMG20A - high mobility group 20A Gene

Homo sapiens

Also known as HMGX1; HMGXB1

Gene ID: 10363 | Gene type: protein coding

About HMG20A

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,420,888-77,520,050 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 20 paralogues. Ubiquitous expression in spleen (RPKM 13.0), testis (RPKM 10.4) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HMG20A Products(3)

mRNA	Protein	Name
NM_001304504.2	NP_001291433.1	high mobility group protein 20A isoform a
NM_001304505.2	NP_001291434.1	high mobility group protein 20A isoform b
NM_018200.4	NP_060670.1	high mobility group protein 20A isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMG20A Protein Structure

HMG_box

0
100
200
300
347 a.a.

Protein Preferred Names

Protein Names

high mobility group protein 20A

HMG box domain containing 1

HMG20A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HMG20A	Q9NP66	CCDC136	Homo sapiens	Q96JN2-2	Y2H Array	25416956
Intra	HMG20A	Q9NP66	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
Intra	HMG20A	Q9NP66	FMNL1	Homo sapiens	O95466-2	Validated Y2H	25416956
Intra	HMG20A	Q9NP66	FMNL1	Homo sapiens	O95466-2	Y2H Prey Pooling	25416956
Intra	HMG20A	Q9NP66	FMNL1	Homo sapiens	O95466-2	Y2H Array	25416956
Intra	HMG20A	Q9NP66	ADD1	Homo sapiens	P35611-5	Y2H Array	25416956
Intra	HMG20A	Q9NP66	GPSM1	Homo sapiens	Q86YR5-3	Y2H Array	32296183
Intra	HMG20A	Q9NP66	GPSM1	Homo sapiens	Q86YR5-3	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	RSPH9	Homo sapiens	Q9H1X1	Validated Y2H	25416956
Intra	HMG20A	Q9NP66	RSPH9	Homo sapiens	Q9H1X1	Y2H Array	25416956
Intra	HMG20A	Q9NP66	RSPH9	Homo sapiens	Q9H1X1	Y2H Prey Pooling	25416956
Intra	HMG20A	Q9NP66	PTH2R	Homo sapiens	P49190	Y2H Prey Pooling	25416956
Intra	HMG20A	Q9NP66	PTH2R	Homo sapiens	P49190	Y2H Array	25416956
Intra	HMG20A	Q9NP66	FOXD4L1	Homo sapiens	Q9NU39	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	PSORS1C2	Homo sapiens	Q9UIG4	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	HMG20A	Q9NP66	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	KPNA2	Homo sapiens	P52292	Y2H Array	25416956
Intra	HMG20A	Q9NP66	RPP30	Homo sapiens	P78346	Y2H Prey Pooling	25416956
Intra	HMG20A	Q9NP66	RPP30	Homo sapiens	P78346	Validated Y2H	25416956
Intra	HMG20A	Q9NP66	RPP30	Homo sapiens	P78346	Y2H Array	31515488
Intra	HMG20A	Q9NP66	HTT	Homo sapiens	P42858	Y2H Prey Pooling	23275563
Intra	HMG20A	Q9NP66	HTT	Homo sapiens	P42858	Lumier	23275563
Intra	HMG20A	Q9NP66	HMG20B	Homo sapiens	Q9P0W2	Anti Tag CoIP	26496610
Intra	HMG20A	Q9NP66	HMG20B	Homo sapiens	Q9P0W2	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	HMG20B	Homo sapiens	Q9P0W2	Anti Tag CoIP	33961781
Intra	HMG20A	Q9NP66	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	HMG20A	Q9NP66	DTNB	Homo sapiens	O60941	Y2H Prey Pooling	25416956
Intra	HMG20A	Q9NP66	DTNB	Homo sapiens	O60941	Validated Y2H	25416956
Intra	HMG20A	Q9NP66	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	33961781
Intra	HMG20A	Q9NP66	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	33961781
Intra	HMG20A	Q9NP66	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	28514442
Intra	HMG20A	Q9NP66	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	26496610
Intra	HMG20A	Q9NP66	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	28514442
Intra	HMG20A	Q9NP66	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	26496610
Intra	HMG20A	Q9NP66	HMG20A	Homo sapiens	Q9NP66	Y2H Array	25416956
Intra	HMG20A	Q9NP66	HMG20A	Homo sapiens	Q9NP66	Y2H Array	20211142
Intra	HMG20A	Q9NP66	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	HMG20A	Q9NP66	HMG20A	Homo sapiens	Q9NP66	Y2H Pooling	16189514
Intra	HMG20A	Q9NP66	TESC	Homo sapiens	Q96BS2	Y2H Pooling	16189514
Intra	HMG20A	Q9NP66	LURAP1	Homo sapiens	Q96LR2	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	LURAP1	Homo sapiens	Q96LR2	Y2H Array	32296183
Intra	HMG20A	Q9NP66	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	HMG20A	Q9NP66	CFAP53	Homo sapiens	Q96M91	Y2H Array	25416956
Intra	HMG20A	Q9NP66	MAGOHB	Homo sapiens	Q96A72	Y2H Pooling	16189514
Intra	HMG20A	Q9NP66	SYTL4	Homo sapiens	Q96C24	Y2H Array	31515488
Intra	HMG20A	Q9NP66	SYTL4	Homo sapiens	Q96C24	Y2H Array	25416956
Intra	HMG20A	Q9NP66	RPRD1B	Homo sapiens	Q9NQG5	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	31515488
Intra	HMG20A	Q9NP66	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	25416956
Intra	HMG20A	Q9NP66	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
Intra	HMG20A	Q9NP66	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	25416956
Intra	HMG20A	Q9NP66	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	25416956
Intra	HMG20A	Q9NP66	HPCAL1	Homo sapiens	P37235	Y2H Array	25416956
Intra	HMG20A	Q9NP66	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	HMG20A	Q9NP66	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	HMG20A	Q9NP66	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	RAD54L2	Homo sapiens	Q9Y4B4	Validated Y2H	32296183
Intra	HMG20A	Q9NP66	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Array	32296183
Intra	HMG20A	Q9NP66	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06228	HMG20A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HMG20A	RGD	RGD:1564760
Mus musculus	HMG20A	MGD	MGI:1914117
Bos taurus	HMG20A	VGNC	VGNC:29873
Macaca mulatta	HMG20A	VGNC	VGNC:73481
Canis familiaris	HMG20A	VGNC	VGNC:41707
Felis catus	HMG20A	VGNC	VGNC:67592

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