1. Gene
  2. TRMT61B - tRNA methyltransferase 61B Gene

TRMT61B - tRNA methyltransferase 61B Gene

Homo sapiens
Gene ID: 55006 | Gene type: protein coding

About TRMT61B

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,849,821-28,870,309 (from NCBI)

This gene has 5 transcripts (splice variants), 182 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 8.4), small intestine (RPKM 6.4) and 25 other tissues.

Summary

Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation; mitochondrial tRNA methylation; and protein homooligomerization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

TRMT61B Products(1)

mRNA Protein Name
NM_017910.4 NP_060380.3 tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mRNA (adenine-N1-)-methyltransferase activity IDA
IDA: Inferred from direct assay
29107537 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
enables rRNA (adenine) methyltransferase activity IMP
IMP: Inferred from mutant phenotype
27631568 GOA
enables tRNA (adenine(58)-N1)-methyltransferase activity IDA
IDA: Inferred from direct assay
23097428 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA processing IDA
IDA: Inferred from direct assay
29107537 GOA
involved in mitochondrial tRNA processing IDA
IDA: Inferred from direct assay
23097428 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
27184847 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
23097428 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT61B Protein Structure

GCD14

GCD14: tRNA methyltransferase complex GCD14 subunit (217 - 467)

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  • 400
  • 477 a.a.
Protein Preferred Names Protein Names

tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial

mRNA methyladenosine-N(1)-methyltransferase

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MELAS

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Diseases Alias
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