PRPF39 - pre-mRNA processing factor 39 Gene

Homo sapiens

Gene ID: 55015 | Gene type: protein coding

About PRPF39

Cytogenetic location: 14q21.2 Genomic coordinates (GRCh38): 14:45,084,116-45,116,282 (from NCBI)

This gene has 12 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in skin (RPKM 15.3), prostate (RPKM 14.2) and 25 other tissues.

Summary

Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP; U2-type prespliceosome; and commitment complex. [provided by Alliance of Genome Resources, Apr 2022]

PRPF39 Products(1)

mRNA	Protein	Name
NM_017922.4	NP_060392.3	pre-mRNA-processing factor 39

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pre-mRNA-processing factor 39

PRP39 homolog

PRPF39 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRPF39	Q86UA1	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	PRPF39	Q86UA1	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	PRPF39	Q86UA1	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	PRPF39	Q86UA1	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PRPF39	Q86UA1	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PRPF39	Q86UA1	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PRPF39	Q86UA1	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	PRPF39	Q86UA1	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	PRPF39	Q86UA1	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	PRPF39	Q86UA1	TOLLIP	Homo sapiens	Q9H0E2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schindler Disease

Alpha-N-Acetylgalactosaminidase Deficiency	Naga Deficiency
Alpha-Galactosidase B Deficiency	Alpha-Galnac Deficiency, Schindler Type
Alpha-Naga Deficiency	Angiokeratoma Corporis Diffusum-Glycopeptiduria
Galb Deficiency	Kanzaki Disease
Lysosomal Glycoaminoacid Storage Disease-Angiokeratoma Corporis Diffusum	Neuroaxonal Dystrophy, Schindler Type
Neuronal Axonal Dystrophy, Schindler Type	Schindler Disease, Type I
Schindler Disease, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11210	PRPF39 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRPF39	VGNC	VGNC:33377
Mus musculus	PRPF39	MGD	MGI:104602
Felis catus	PRPF39	VGNC	VGNC:64373
Rattus norvegicus	PRPF39	RGD	RGD:1308702
Macaca mulatta	PRPF39	VGNC	VGNC:76292
Canis familiaris	PRPF39	VGNC	VGNC:45024

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