PPP1R7 - protein phosphatase 1 regulatory subunit 7 Gene

Homo sapiens

Also known as SDS22

Gene ID: 5510 | Gene type: protein coding

About PPP1R7

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,149,573-241,183,652 (from NCBI)

This gene has 20 transcripts (splice variants), 113 orthologues and 10 paralogues. Broad expression in testis (RPKM 40.9), brain (RPKM 18.7) and 25 other tissues.

Summary

This gene encodes a protein subunit that regulates the activity of the serine/threonine Phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PPP1R7 Products(7)

mRNA	Protein	Name
NM_001282409.1	NP_001269338.1	protein phosphatase 1 regulatory subunit 7 isoform 2
NM_001282410.1	NP_001269339.1	protein phosphatase 1 regulatory subunit 7 isoform 3
NM_001282411.1	NP_001269340.1	protein phosphatase 1 regulatory subunit 7 isoform 4
NM_001282412.1	NP_001269341.1	protein phosphatase 1 regulatory subunit 7 isoform 5
NM_001282413.1	NP_001269342.1	protein phosphatase 1 regulatory subunit 7 isoform 6
NM_001282414.1	NP_001269343.1	protein phosphatase 1 regulatory subunit 7 isoform 7
NM_002712.3	NP_002703.1	protein phosphatase 1 regulatory subunit 7 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23414517	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome	IDA IDA: Inferred from direct assay	22801782	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R7 Protein Structure

LRR_9

LRR_4

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 7

protein phosphatase 1 regulatory subunit 22

PPP1R7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R7	Q15435	PPP1CB	Homo sapiens	P62140	Y2H Array	32296183
Intra	PPP1R7	Q15435	PPP1CB	Homo sapiens	P62140	Y2H Fragment Pooling	23414517
Intra	PPP1R7	Q15435	PPP1CB	Homo sapiens	P62140	Y2H Prey Pooling	32296183
Intra	PPP1R7	Q15435	PPP1CB	Homo sapiens	P62140	TAP	27173435
Intra	PPP1R7	Q15435	PPP1CC	Homo sapiens	P36873	Anti Tag CoIP	33961781
Intra	PPP1R7	Q15435	PPP1CC	Homo sapiens	P36873	TAP	27173435
Intra	PPP1R7	Q15435	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	33961781
Intra	PPP1R7	Q15435	PPP1CA	Homo sapiens	P62136	TAP	27173435
Intra	PPP1R7	Q15435	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	28514442
Intra	PPP1R7	Q15435	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	PPP1R7	Q15435	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11003	PPP1R7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP1R7	VGNC	VGNC:99395
Felis catus	PPP1R7	VGNC	VGNC:80318
Rattus norvegicus	PPP1R7	RGD	RGD:1308169
Bos taurus	PPP1R7	VGNC	VGNC:52808
Canis familiaris	PPP1R7	VGNC	VGNC:59089
Mus musculus	PPP1R7	MGD	MGI:1913635
Others	PPP1R7	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.