PPP1R8 - protein phosphatase 1 regulatory subunit 8 Gene

Homo sapiens

Also known as ARD1; ARD-1; NIPP1; NIPP-1; PRO2047

Gene ID: 5511 | Gene type: protein coding

About PPP1R8

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,830,782-27,851,676 (from NCBI)

This gene has 5 transcripts (splice variants), 242 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 13.4), lymph node (RPKM 13.2) and 25 other tissues.

Summary

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the Phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

PPP1R8 Products(3)

mRNA	Protein	Name
NM_002713.4	NP_002704.1	nuclear inhibitor of protein phosphatase 1 isoform gamma
NM_014110.5	NP_054829.2	nuclear inhibitor of protein phosphatase 1 isoform alpha
NM_138558.3	NP_612568.1	nuclear inhibitor of protein phosphatase 1 isoform beta/delta

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular function inhibitor activity	EXP EXP: Inferred from Experiment	22940584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11739654	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	11739654	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R8 Protein Structure

FHA

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

nuclear inhibitor of protein phosphatase 1

RNase E

PPP1R8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R8	Q12972	PPP1CA	Homo sapiens	P62136	Y2H	22365833
Intra	PPP1R8	Q12972	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	18842582
Intra	PPP1R8	Q12972	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	33961781
Intra	PPP1R8	Q12972	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	PPP1R8	Q12972	APPBP2	Homo sapiens	Q92624	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xia-Gibbs Syndrome

Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome	XIGIS
Mrd25	Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome
Mental Retardation, Autosomal Dominant 25, Formerly	Mrd25, Formerly
Autosomal Dominant Mental Retardation 25	Autosomal Dominant Intellectual Disability 25
Xgs

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11004	PPP1R8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP1R8	RGD	RGD:1306280
Mus musculus	PPP1R8	MGD	MGI:2140494
Felis catus	PPP1R8	VGNC	VGNC:69005
Bos taurus	PPP1R8	VGNC	VGNC:33249

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