CEP192 - centrosomal protein 192 Gene

Homo sapiens

Also known as PPP1R62

Gene ID: 55125 | Gene type: protein coding

About CEP192

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,991,362-13,125,036 (from NCBI)

This gene has 14 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 8.2), gall bladder (RPKM 6.1) and 25 other tissues.

Summary

Enables Phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole; centrosome; and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CEP192 Products(1)

mRNA	Protein	Name
NM_032142.4	NP_115518.3	centrosomal protein of 192 kDa

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IDA IDA: Inferred from direct assay	19389623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19389623	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome-templated microtubule nucleation	IMP IMP: Inferred from mutant phenotype	17980596	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	17980596	GOA
involved in protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	17980596	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	32060285	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17980596	GOA
located in procentriole	IDA IDA: Inferred from direct assay	24997597	GOA
part of procentriole replication complex	IPI IPI: Inferred from physical interaction	24997597	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

centrosomal protein of 192 kDa

192 kDa centrosomal protein

CEP192 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEP192	Q8TEP8	NUP50	Homo sapiens	Q9UKX7	Anti Bait CoIP	35709258
Intra	CEP192	Q8TEP8	PLK4	Homo sapiens	O00444	Anti Bait CoIP	24997597

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Dominant Intellectual Developmental Disorder 40

Autosomal Dominant Non-Syndromic Intellectual Disability 40	Autosomal Dominant Mental Retardation 40
Mrd40	Mental Retardation, Autosomal Dominant 40

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Ovarian Endometrioid Stromal Sarcoma

Ovary Sarcoma

Sarcoma Of Ovary

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02508	CEP192 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CEP192	RGD	RGD:1562797
Bos taurus	CEP192	VGNC	VGNC:27199
Felis catus	CEP192	VGNC	VGNC:82467
Mus musculus	CEP192	MGD	MGI:1918049
Canis familiaris	CEP192	VGNC	VGNC:58297

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