NUP50 - nucleoporin 50 Gene

Homo sapiens

Also known as NPAP60; NPAP60L

Gene ID: 10762 | Gene type: protein coding

About NUP50

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:45,163,925-45,188,017 (from NCBI)

This gene has 19 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in bone marrow (RPKM 16.3), lymph node (RPKM 14.7) and 25 other tissues.

Summary

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NUP50 Products(2)

mRNA	Protein	Name
NM_007172.4	NP_009103.2	nuclear pore complex protein Nup50 isoform b
NM_153645.2	NP_705931.1	nuclear pore complex protein Nup50 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12802065	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	24315095	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	12802065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP50 Protein Structure

NUP50

Ran_BP1

0
100
200
300
400
468 a.a.

Protein Preferred Names

Protein Names

nuclear pore complex protein Nup50

50 kDa nucleoporin

NUP50 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUP50	Q9UKX7	KPNA2	Homo sapiens	Q7Z726	Y2H Array	25416956
Intra	NUP50	Q9UKX7	KPNA2	Homo sapiens	P52292	Y2H Array	25416956
Intra	NUP50	Q9UKX7	KPNA2	Homo sapiens	P52292	Y2H Array	32296183
Intra	NUP50	Q9UKX7	KPNA2	Homo sapiens	P52292	Anti Tag CoIP	33961781
Intra	NUP50	Q9UKX7	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	25416956
Intra	NUP50	Q9UKX7	KPNA2	Homo sapiens	P52292	Validated Y2H	25416956
Intra	NUP50	Q9UKX7	KPNA2	Homo sapiens	P52292	Y2H Prey Pooling	32296183
Intra	NUP50	Q9UKX7	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	25416956
Intra	NUP50	Q9UKX7	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	32296183
Intra	NUP50	Q9UKX7	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	33961781
Intra	NUP50	Q9UKX7	KPNA3	Homo sapiens	O00505	Y2H Array	32296183
Intra	NUP50	Q9UKX7	KPNA1	Homo sapiens	P52294	Y2H Prey Pooling	32296183
Intra	NUP50	Q9UKX7	KPNA1	Homo sapiens	P52294	Y2H Array	25416956
Intra	NUP50	Q9UKX7	KPNA1	Homo sapiens	P52294	Y2H Array	32296183
Intra	NUP50	Q9UKX7	KPNA1	Homo sapiens	P52294	Anti Tag CoIP	33961781
Intra	NUP50	Q9UKX7	KPNA1	Homo sapiens	P52294	Y2H Array	31515488
Intra	NUP50	Q9UKX7	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	25416956
Intra	NUP50	Q9UKX7	KPNA6	Homo sapiens	O60684	Y2H Prey Pooling	32296183
Intra	NUP50	Q9UKX7	KPNA6	Homo sapiens	O60684	Anti Tag CoIP	33961781
Intra	NUP50	Q9UKX7	KPNA6	Homo sapiens	O60684	Y2H Array	32296183
Intra	NUP50	Q9UKX7	KPNA4	Homo sapiens	O00629	Y2H Array	32296183
Intra	NUP50	Q9UKX7	KPNA4	Homo sapiens	O00629	Y2H Prey Pooling	25416956
Intra	NUP50	Q9UKX7	KPNA4	Homo sapiens	O00629	Anti Tag CoIP	33961781
Intra	NUP50	Q9UKX7	KPNA4	Homo sapiens	O00629	Y2H Prey Pooling	32296183
Intra	NUP50	Q9UKX7	KPNA5	Homo sapiens	O15131	Y2H Array	31515488
Intra	NUP50	Q9UKX7	KPNA5	Homo sapiens	O15131	Y2H Array	32296183
Intra	NUP50	Q9UKX7	KPNA5	Homo sapiens	O15131	Y2H Array	25416956
Intra	NUP50	Q9UKX7	KPNA5	Homo sapiens	O15131	Anti Tag CoIP	33961781
Intra	NUP50	Q9UKX7	KPNA5	Homo sapiens	O15131	Y2H Prey Pooling	32296183
Intra	NUP50	Q9UKX7	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	NUP50	Q9UKX7	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09695	NUP50 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NUP50	VGNC	VGNC:68599
Canis familiaris	NUP50	VGNC	VGNC:44056
Rattus norvegicus	NUP50	RGD	RGD:3191
Mus musculus	NUP50	MGD	MGI:1351502
Macaca mulatta	NUP50	VGNC	VGNC:75561
Bos taurus	NUP50	VGNC	VGNC:32362
Others	NUP50	NCBI

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