HAUS2 - HAUS augmin like complex subunit 2 Gene

Homo sapiens

Also known as CEP27; C15orf25; HsT17025

Gene ID: 55142 | Gene type: protein coding

About HAUS2

Cytogenetic location: 15q15.2 Genomic coordinates (GRCh38): 15:42,548,838-42,569,994 (from NCBI)

This gene has 10 transcripts (splice variants) and 185 orthologues. Ubiquitous expression in bone marrow (RPKM 7.1), brain (RPKM 3.8) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]

HAUS2 Products(6)

mRNA	Protein	Name
NM_001130447.2	NP_001123919.1	HAUS augmin-like complex subunit 2 isoform 2
NM_001323629.2	NP_001310558.1	HAUS augmin-like complex subunit 2 isoform 3
NM_001323630.2	NP_001310559.1	HAUS augmin-like complex subunit 2 isoform 4
NM_001323631.2	NP_001310560.1	HAUS augmin-like complex subunit 2 isoform 5
NM_001323632.2	NP_001310561.1	HAUS augmin-like complex subunit 2 isoform 5
NM_018097.3	NP_060567.1	HAUS augmin-like complex subunit 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19369198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	19427217	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	19369198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of HAUS complex	IDA IDA: Inferred from direct assay	19369198	GOA
part of HAUS complex	IPI IPI: Inferred from physical interaction	20360068	GOA
located in centrosome	IDA IDA: Inferred from direct assay	14654843	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAUS2 Protein Structure

HAUS2

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

HAUS augmin-like complex subunit 2

centrosomal protein 27kDa

HAUS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAUS2	Q9NVX0	HAUS6	Homo sapiens	Q7Z4H7	DLS	25173975
Intra	HAUS2	Q9NVX0	HAUS6	Homo sapiens	Q7Z4H7	TEM	25173975
Intra	HAUS2	Q9NVX0	HAUS6	Homo sapiens	Q7Z4H7	TAP	24981860
Intra	HAUS2	Q9NVX0	HAUS6	Homo sapiens	Q7Z4H7	Anti Tag CoIP	26496610
Intra	HAUS2	Q9NVX0	HAUS6	Homo sapiens	Q7Z4H7	TAP	20360068
Intra	HAUS2	Q9NVX0	HAUS6	Homo sapiens	Q7Z4H7	GMS	25173975
Intra	HAUS2	Q9NVX0	HAUS6	Homo sapiens	Q7Z4H7	SLS	25173975

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Patella, Chondromalacia Of

Chondromalacia Patellae	Chondromalacia Of Patella
Softening Of Articular Cartilage Of Patella	Patellofemoral Pain Syndrome
Patellofemoral Chondromalacia

Meckel Syndrome, Type 8

Meckel Syndrome 8	MKS8
Meckel-Gruber Syndrome, Type 8

Laryngeal Benign Neoplasm

Laryngeal Tumor	Larynx Neoplasm
Neoplasm Of Larynx	Laryngeal Cancer
Laryngeal Carcinoma	Cancer Of Larynx

Glycerol Kinase Deficiency

Hyperglycerolemia	GKD
Gk Deficiency	Gk1 Deficiency
Deficiency Of Glycerol Kinase	Isolated Glycerol Kinase Deficiency
Glycerol Kinase Deficiency, Adult Form	Glycerol Kinase Deficiency, Juvenile Form
Deficiency, Glycerol Kinase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06014	HAUS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HAUS2	VGNC	VGNC:29758
Canis familiaris	HAUS2	VGNC	VGNC:41603
Felis catus	HAUS2	VGNC	VGNC:80958
Mus musculus	HAUS2	MGD	MGI:1913546
Rattus norvegicus	HAUS2	RGD	RGD:9250626
Macaca mulatta	HAUS2	VGNC	VGNC:73231

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