2. Gene
  3. CDCA8 - cell division cycle associated 8 Gene

CDCA8 - cell division cycle associated 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BOR; DasraB; MESRGP; BOREALIN

Gene ID: 55143 | Gene type: protein coding

About CDCA8

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,692,516-37,709,719 (from NCBI)

This gene has 2 transcripts (splice variants) and 210 orthologues. Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues.

Summary

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

CDCA8 Products(2)

mRNA Protein Name
NM_001256875.2 NP_001243804.1 borealin
NM_018101.4 NP_060571.1 borealin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16239925 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromosome organization IMP
IMP: Inferred from mutant phenotype
15260989 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
15260989 GOA
Cellular Component GO Annotation Evidence Reference Source
part of chromosome passenger complex IPI
IPI: Inferred from physical interaction
15260989 GOA
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
15260989 GOA
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
9859993 GOA
located in midbody IDA
IDA: Inferred from direct assay
22724069 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
16239925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA8 Protein Structure

Nbl1_Borealin_N

Nbl1_Borealin_N: Nbl1 / Borealin N terminal (19 - 76)

Borealin

Borealin: Cell division cycle-associated protein 8 (163 - 277)

  • 0
  • 100
  • 200
  • 280 a.a.
Protein Preferred Names Protein Names

borealin

Dasra B

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02317 CDCA8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDCA8 RGD RGD:1566306
Mus musculus CDCA8 MGD MGI:1196274
Bos taurus CDCA8 VGNC VGNC:27088
Macaca mulatta CDCA8 VGNC VGNC:70714
Felis catus CDCA8 VGNC VGNC:60670
Canis familiaris CDCA8 VGNC VGNC:39017