1. Gene
  2. CDCA8 - cell division cycle associated 8 Gene

CDCA8 - cell division cycle associated 8 Gene

Homo sapiens

Also known as BOR; DasraB; MESRGP; BOREALIN

Gene ID: 55143 | Gene type: protein coding

About CDCA8

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,692,516-37,709,719 (from NCBI)

This gene has 2 transcripts (splice variants) and 210 orthologues. Biased expression in testis (RPKM 14.3), bone marrow (RPKM 12.4) and 13 other tissues.

Summary

This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

CDCA8 Products(2)

mRNA Protein Name
NM_001256875.2 NP_001243804.1 borealin
NM_018101.4 NP_060571.1 borealin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16239925 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromosome organization IMP
IMP: Inferred from mutant phenotype
15260989 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
15260989 GOA
Cellular Component GO Annotation Evidence Reference Source
part of chromosome passenger complex IPI
IPI: Inferred from physical interaction
15260989 GOA
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
15260989 GOA
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
9859993 GOA
located in midbody IDA
IDA: Inferred from direct assay
22724069 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
16239925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA8 Protein Structure

Nbl1_Borealin_N

Nbl1_Borealin_N: Nbl1 / Borealin N terminal (19 - 76)

Borealin

Borealin: Cell division cycle-associated protein 8 (163 - 277)

  • 0
  • 100
  • 200
  • 280 a.a.
Protein Preferred Names Protein Names

borealin

Dasra B

CDCA8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CDCA8 Q53HL2 PIH1D2 Homo sapiens Q8WWB5 32296183
Intra
CDCA8 Q53HL2 EMILIN1 Homo sapiens Q9Y6C2-2 32296183
Intra
CDCA8 Q53HL2 SPANXN2 Homo sapiens Q5MJ10 32296183
Intra
CDCA8 Q53HL2 FBXO17 Homo sapiens Q96EF6 32296183
Intra
CDCA8 Q53HL2 HMBOX1 Homo sapiens Q6NT76 32296183
Intra
CDCA8 Q53HL2 INCENP Homo sapiens Q9NQS7 20739936
Intra
CDCA8 Q53HL2 INCENP Homo sapiens Q9NQS7
Y2H
17956729
Intra
CDCA8 Q53HL2 INCENP Homo sapiens Q9NQS7 17956729
Intra
CDCA8 Q53HL2 NKAPD1 Homo sapiens Q6ZUT1 32296183
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 17956729
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 17099693
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 20739936
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 18243099
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392
Y2H
17956729
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 17956729
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 20739936
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 33961781
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392 17099693
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392-1 16291752
Intra
CDCA8 Q53HL2 BIRC5 Homo sapiens O15392-2 16291752
Intra
CDCA8 Q53HL2 AURKB Homo sapiens Q96GD4 20739936
Intra
CDCA8 Q53HL2 AURKB Homo sapiens Q96GD4 17956729
Intra
CDCA8 Q53HL2 AURKB Homo sapiens Q96GD4 18243099
Intra
CDCA8 Q53HL2 AURKB Homo sapiens Q96GD4 20739936
Intra
CDCA8 Q53HL2 NTAQ1 Homo sapiens Q96HA8 32296183
Intra
CDCA8 Q53HL2 RPRD1B Homo sapiens Q9NQG5 32296183
Intra
CDCA8 Q53HL2 GAS2L3 Homo sapiens Q86XJ1 24571573
Intra
CDCA8 Q53HL2 SGO1 Homo sapiens Q5FBB7
Y2H
20739936
Intra
CDCA8 Q53HL2 SGO1 Homo sapiens Q5FBB7 20739936
Intra
CDCA8 Q53HL2 SGO2 Homo sapiens Q562F6
Y2H
20739936
Intra
CDCA8 Q53HL2 SGO2 Homo sapiens Q562F6 20739936
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDCA8 RGD RGD:1566306
Mus musculus CDCA8 MGD MGI:1196274
Bos taurus CDCA8 VGNC VGNC:27088
Macaca mulatta CDCA8 VGNC VGNC:70714
Felis catus CDCA8 VGNC VGNC:60670
Canis familiaris CDCA8 VGNC VGNC:39017