2. Gene
  3. AURKB - aurora kinase B Gene

AURKB - aurora kinase B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2

Gene ID: 9212 | Gene type: protein coding

About AURKB

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,204,731-8,210,575 (from NCBI)

This gene has 14 transcripts (splice variants), 216 orthologues and 2 paralogues. Biased expression in lymph node (RPKM 11.6), bone marrow (RPKM 10.7) and 11 other tissues.

Summary

This gene encodes a member of the Aurora Kinase subfamily of serine/threonine kinases. The genes encoding the Other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

AURKB Products(15)

mRNA Protein Name
NR_132731.1
NM_001313955.2 NP_001300884.1 aurora kinase B isoform 7
NM_001313950.2 NP_001300879.1 aurora kinase B isoform 1
XM_017025311.2 XP_016880800.1 aurora kinase B isoform X3
XM_047437051.1 XP_047293007.1 aurora kinase B isoform X2
NM_001313954.2 NP_001300883.1 aurora kinase B isoform 6
NM_001313951.1 NP_001300880.1 aurora kinase B isoform 2
NM_001284526.2 NP_001271455.1 aurora kinase B isoform 3
XM_011524072.4 XP_011522374.1 aurora kinase B isoform X1
XM_047437050.1 XP_047293006.1 aurora kinase B isoform X1
NM_001313952.2 NP_001300881.1 aurora kinase B isoform 4
NM_001313953.3 NP_001300882.1 aurora kinase B isoform 5
NR_132730.2
NM_004217.4 NP_004208.2 aurora kinase B isoform 1
NM_001256834.3 NP_001243763.1 aurora kinase B isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables kinase binding IPI
IPI: Inferred from physical interaction
23036704 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12689593 GOA
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
21397845 GOA
NOT enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
26829474 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18455984 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell cycle G2/M phase transition IDA
IDA: Inferred from direct assay
33542149 GOA
involved in cellular response to UV IDA
IDA: Inferred from direct assay
20959462 GOA
involved in cleavage furrow formation IDA
IDA: Inferred from direct assay
16103226 GOA
involved in mitotic sister chromatid biorientation IDA
IDA: Inferred from direct assay
22371557 GOA
involved in mitotic spindle midzone assembly IMP
IMP: Inferred from mutant phenotype
16103226 GOA
involved in negative regulation of B cell apoptotic process IDA
IDA: Inferred from direct assay
20959462 GOA
involved in negative regulation of cGAS/STING signaling pathway IDA
IDA: Inferred from direct assay
33542149 GOA
involved in negative regulation of innate immune response IDA
IDA: Inferred from direct assay
33542149 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20959462 GOA
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
16103226 GOA
involved in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
28751710 GOA
involved in positive regulation of microtubule depolymerization IDA
IDA: Inferred from direct assay
31804178 GOA
involved in positive regulation of mitotic sister chromatid segregation IDA
IDA: Inferred from direct assay
26829474 GOA
acts upstream of or within positive regulation of telomere maintenance IMP
IMP: Inferred from mutant phenotype
21531765 GOA
involved in protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
19468067 GOA
involved in repair of mitotic kinetochore microtubule attachment defect IDA
IDA: Inferred from direct assay
22371557 GOA
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
21820309 GOA
Cellular Component GO Annotation Evidence Reference Source
part of chromosome passenger complex IPI
IPI: Inferred from physical interaction
15260989 GOA
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
18195732 GOA
is active in kinetochore IDA
IDA: Inferred from direct assay
26829474 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
22024163 GOA
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
9859993 GOA
located in midbody IDA
IDA: Inferred from direct assay
17726514 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20959462 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AURKB Protein Structure

Pkinase

Pkinase: Protein kinase domain (77 - 327)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

aurora kinase B

aurora kinase B-Sv1

aurora kinase B-Sv2

aurora- and Ipl1-like midbody-associated protein 1

aurora-1

aurora-B

aurora-related kinase 2

aurora/IPL1-related kinase 2

protein phosphatase 1, regulatory subunit 48

serine/threonine kinase 12

serine/threonine-protein kinase 12

serine/threonine-protein kinase 5

serine/threonine-protein kinase aurora-B

AURKB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AURKB Q96GD4 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
33961781
Intra
AURKB Q96GD4 HSP90AA5P Homo sapiens Q58FG0
Anti Tag CoIP
28514442
Intra
AURKB Q96GD4 VRK1 Homo sapiens Q99986
Protein Kinase Assay
29340707
Intra
AURKB Q96GD4 KLHL13 Homo sapiens Q9P2N7
Pull Down
17543862
Intra
AURKB Q96GD4 KLHL9 Homo sapiens Q9P2J3
Pull Down
17543862
Intra
AURKB Q96GD4 USP29 Homo sapiens Q9HBJ7
Anti Bait CoIP
38233848
Intra
AURKB Q96GD4 CDC37 Homo sapiens Q16543
Anti Tag CoIP
35271311
Intra
AURKB Q96GD4 CDC37 Homo sapiens Q16543
Lumier
25036637
Intra
AURKB Q96GD4 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra
AURKB Q96GD4 CDC37 Homo sapiens Q16543
BioID
29568061
Intra
AURKB Q96GD4 CDC37 Homo sapiens Q16543
Pull Down
29568061
Intra
AURKB Q96GD4 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
26829474
Intra
AURKB Q96GD4 PPP2R1A Homo sapiens P30153
Pull Down
32707033
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
19357306
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
27332895
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Bait CoIP
27332895
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
17956729
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Pull Down
29568061
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Pull Down
32707033
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
35271311
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Y2H
20739936
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
33961781
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
BioID
29568061
Intra
AURKB Q96GD4 INCENP Homo sapiens Q9NQS7
PLA
21051298
Intra
AURKB Q96GD4 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra
AURKB Q96GD4 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
28514442
Intra
AURKB Q96GD4 HSP90AB1 Homo sapiens P08238
Pull Down
29568061
Intra
AURKB Q96GD4 H3-4 Homo sapiens Q16695
Protein Kinase Assay
29340707
Intra
AURKB Q96GD4 KAT5 Homo sapiens Q92993
GMS
26829474
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
Pull Down
16291752
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
BioID
29568061
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Tag CoIP
27332895
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
Pull Down
17099693
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Tag CoIP
19357306
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Bait CoIP
27332895
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
PLA
21051298
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Tag CoIP
17099693
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392
Anti Bait CoIP
17681274
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392-1
Pull Down
16291752
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392-1
Anti Tag CoIP
16291752
Intra
AURKB Q96GD4 BIRC5 Homo sapiens O15392-2
Pull Down
16291752
Intra
AURKB Q96GD4 TACC1 Homo sapiens O75410-6
Anti Tag CoIP
15064709
Intra
AURKB Q96GD4 SEPTIN1 Homo sapiens Q8WYJ6
Anti Tag CoIP
16179162
Intra
AURKB Q96GD4 SEPTIN1 Homo sapiens Q8WYJ6
Y2H
16179162
Intra
AURKB Q96GD4 NPM1 Homo sapiens P06748
Anti Tag CoIP
24857377
Intra
AURKB Q96GD4 NPM1 Homo sapiens P06748
Pull Down
24857377
Intra
AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
PLA
21051298
Intra
AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
Anti Bait CoIP
20739936
Intra
AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
BioID
29568061
Intra
AURKB Q96GD4 CDCA8 Homo sapiens Q53HL2
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

AURKB Antibodies

Cat. No. Product Name Application Reactivity
HY-P80562 Aurora B Antibody WB, IP Human

Related Diseases

Diseases Alias
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Endometrial Serous Adenocarcinoma

Uterine Corpus Serous Adenocarcinoma

Uterine Papillary Serous Carcinoma

Uterine Serous Carcinoma
Nystagmus 3, Congenital, Autosomal Dominant

NYS3

Congenital Nystagmus 3

Autosomal Dominant Congenital Nystagmus 3
Polyploidy

Polyploid

Polyploidy Syndrome
Nk-Cell Enteropathy
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-157396 JAB-2485 98.11% Unkown
HY-151971 Aurora Kinases-IN-3 Inhibitor 98.47% Unkown
HY-157480 EGFR/AURKB-IN-1 Inhibitor 99.43% Unkown
HY-RS01270 AURKB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-10338A Foretinib phosphate Inhibitor / Unkown
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123610 BRD-7880 Inhibitor / Unkown
HY-168540 PROTAC MPS1 degrader 1 Degrader / Unkown
HY-168543 PROTAC MPS1 degrader 2 Degrader / Unkown
HY-RS01271 Aurkb Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01272 Aurkb Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AURKB VGNC VGNC:26351
Canis familiaris AURKB VGNC VGNC:38312
Macaca mulatta AURKB VGNC VGNC:70050
Mus musculus AURKB MGD MGI:107168
Felis catus AURKB VGNC VGNC:60044
Rattus norvegicus AURKB RGD RGD:621625