MAP1S - microtubule associated protein 1S Gene

Homo sapiens

Also known as MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1

Gene ID: 55201 | Gene type: protein coding

About MAP1S

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,719,480-17,734,513 (from NCBI)

This gene has 21 transcripts (splice variants), 242 orthologues and 2 paralogues. Broad expression in testis (RPKM 11.7), brain (RPKM 7.0) and 25 other tissues.

Summary

Enables DNA binding activity and cytoskeletal protein binding activity. Involved in microtubule bundle formation; neuron projection morphogenesis; and regulation of chromatin disassembly. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MAP1S Products(2)

mRNA	Protein	Name
NM_001308363.2	NP_001295292.1	microtubule-associated protein 1S isoform 2
NM_018174.6	NP_060644.4	microtubule-associated protein 1S isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15907802	GOA
NOT enables DNA nuclease activity	IDA IDA: Inferred from direct assay	15907802	GOA
NOT enables actin filament binding	IDA IDA: Inferred from direct assay	12762840	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	15528209	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	12762840	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	15528209	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12762840	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	15528209	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	17234756	GOA
involved in microtubule anchoring at centrosome	IMP IMP: Inferred from mutant phenotype	17234756	GOA
involved in microtubule bundle formation	IMP IMP: Inferred from mutant phenotype	15528209	GOA
involved in mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	17234756	GOA
involved in neuron projection morphogenesis	IEP IEP: Inferred from expression pattern	15528209	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	17658481	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17234756	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12762840	GOA
located in microtubule	IDA IDA: Inferred from direct assay	15528209	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	17234756	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	17234756	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12762840	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12762840	GOA
located in spindle	IDA IDA: Inferred from direct assay	18445686	GOA
located in synapse	IDA IDA: Inferred from direct assay	17658481	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microtubule-associated protein 1S

BPY2-interacting protein 1

MAP1S Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP1S	Q66K74	BPY2C	Homo sapiens	O14599	Y2H Pooling	14627543
Intra	MAP1S	Q66K74	BPY2C	Homo sapiens	O14599	Anti Tag CoIP	14627543
Intra	MAP1S	Q66K74	SOCS3	Homo sapiens	O14543	IF	19027008
Intra	MAP1S	Q66K74	SOCS3	Homo sapiens	O14543	Pull Down	19027008
Intra	MAP1S	Q66K74	SOCS3	Homo sapiens	O14543	Y2H	19027008

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Osteogenesis Imperfecta, Type Xviii

OI18	Osteogenesis Imperfecta Type 18
Osteogenesis Imperfecta, Type 18	Osteogenesis Imperfecta 18

Osteogenesis Imperfecta, Type Viii

Osteogenesis Imperfecta Type 8	OI8
Osteogenesis Imperfecta Type Viii	Oi Type Viii
Oi, Type Viii	Osteogenesis Imperfecta 8
Oi-Viii

Giant Axonal Neuropathy 1, Autosomal Recessive

Giant Axonal Neuropathy	Giant Axonal Neuropathy 1
Gan	GAN1
Giant Axonal Neuropathy-1	Neuropathy, Giant Axonal
Giant Axonal Disease	Neuropathy, Axonal, Giant, Type 1

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08031	MAP1S Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP1S	MGD	MGI:2443304
Rattus norvegicus	MAP1S	RGD	RGD:1308266
Bos taurus	MAP1S	VGNC	VGNC:31181
Canis familiaris	MAP1S	VGNC	VGNC:42958
Macaca mulatta	MAP1S	VGNC	VGNC:74294

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