KLHDC8A - kelch domain containing 8A Gene

Homo sapiens

Gene ID: 55220 | Gene type: protein coding

About KLHDC8A

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,336,061-205,357,039 (from NCBI)

This gene has 12 transcripts (splice variants), 126 orthologues and 54 paralogues. Biased expression in ovary (RPKM 76.6) and adrenal (RPKM 7.3).

Summary

This gene encodes a kelch domain-containing protein which is upregulated in Cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

KLHDC8A Products(4)

mRNA	Protein	Name
NM_001271863.2	NP_001258792.1	kelch domain-containing protein 8A
NM_001271864.2	NP_001258793.1	kelch domain-containing protein 8A
NM_001271865.2	NP_001258794.1	kelch domain-containing protein 8A
NM_018203.3	NP_060673.1	kelch domain-containing protein 8A

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHDC8A Protein Structure

Kelch_1

Kelch_6

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

kelch domain-containing protein 8A

S-delta-E1

KLHDC8A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLHDC8A	Q8IYD2	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	33961781
Intra	KLHDC8A	Q8IYD2	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Astrocytoma, Idh-Mutant, Grade 4

Idh-Mutant Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07352	KLHDC8A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLHDC8A	MGD	MGI:2442630
Macaca mulatta	KLHDC8A	VGNC	VGNC:74124
Felis catus	KLHDC8A	VGNC	VGNC:63139
Bos taurus	KLHDC8A	VGNC	VGNC:30639
Canis familiaris	KLHDC8A	VGNC	VGNC:42443
Rattus norvegicus	KLHDC8A	RGD	RGD:1305132

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