PTPA - protein phosphatase 2 phosphatase activator Gene

Homo sapiens

Also known as PP2A; PR53; PPP2R4

Gene ID: 5524 | Gene type: protein coding

About PTPA

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,110,950-129,148,946 (from NCBI)

This gene has 24 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 35.1), brain (RPKM 26.2) and 25 other tissues.

Summary

Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl Phosphatase activator of the dimeric form of protein Phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PTPA Products(6)

mRNA	Protein	Name
NM_001193397.2	NP_001180326.1	serine/threonine-protein phosphatase 2A activator isoform e
NM_001271832.2	NP_001258761.1	serine/threonine-protein phosphatase 2A activator isoform f
NM_021131.5	NP_066954.2	serine/threonine-protein phosphatase 2A activator isoform b
NM_178000.3	NP_821067.1	serine/threonine-protein phosphatase 2A activator isoform b
NM_178001.3	NP_821068.1	serine/threonine-protein phosphatase 2A activator isoform a
NM_178003.3	NP_821070.1	serine/threonine-protein phosphatase 2A activator isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16916641	GOA
enables phosphatase binding	IDA IDA: Inferred from direct assay	16916641	GOA
contributes to phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein tyrosine phosphatase activator activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	10830164	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	17333320	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ATPase complex	IDA IDA: Inferred from direct assay	16916641	GOA
part of calcium channel complex	IDA IDA: Inferred from direct assay	10830164	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17333320	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17333320	GOA
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	10318862	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPA Protein Structure

PTPA

0
100
200
300
358 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A activator

PP2A phosphatase activator

Related Diseases

Diseases

Alias

Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia	Acute Leukemia Of Ambiguous Lineage
Acute Undifferentiated Leukemia	Acute Leukemia Of Indeterminate Lineage
Hybrid Acute Leukemia	Mixed Lineage Acute Leukemia
All With Myeloid Markers	Aml With Lymphoid Markers
Acute Leukemia Of Undetermined Lineage	Bal
Biphenotypic Acute Leukemia	Undifferentiated Acute Leukemia
Mpal	Acute Myeloid Leukemia, Minimal Differentiation, Fab M0
Leukemia, Biphenotypic, Acute

Chromosome 13q14 Deletion Syndrome

Chromosome 13q Deletion Syndrome	Deletion 13q14
Chromosome 13q Deletion	13q Deletion
13q Monosomy	Deletion 13q
Monosomy 13q	Monosomy 13q14
Del(13)(Q14)

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11412	PTPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-158570	(2E)-Eicosenoic acid	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTPA	VGNC	VGNC:76583
Canis familiaris	PTPA	VGNC	VGNC:45164
Felis catus	PTPA	VGNC	VGNC:97576
Bos taurus	PTPA	VGNC	VGNC:33526
Mus musculus	PTPA	MGD	MGI:1346006
Rattus norvegicus	PTPA	RGD	RGD:1308354
Others	PTPA	NCBI

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