UBE2W - ubiquitin conjugating enzyme E2 W Gene

Homo sapiens

Also known as UBC16; UBC-16

Gene ID: 55284 | Gene type: protein coding

About UBE2W

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,780,096-73,878,862 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a nuclear-localized ubiquitin-conjugating Enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) Enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

UBE2W Products(3)

mRNA	Protein	Name
NM_001001481.4	NP_001001481.3	ubiquitin-conjugating enzyme E2 W isoform 1
NM_001271015.3	NP_001257944.2	ubiquitin-conjugating enzyme E2 W isoform 3
NM_018299.6	NP_060769.5	ubiquitin-conjugating enzyme E2 W isoform 2

UBE2W Protein Structure

UQ_con

0
100
151 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 W

E2 ubiquitin-conjugating enzyme W

Recombinant UBE2W Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77272	UBE2W Protein, Human (His)	Q96B02-1 (M1-C151)	≥95%

Related Diseases

Diseases

Alias

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16	SCAR16
Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency	Spinocerebellar Ataxia Autosomal Recessive Type 16
Spinocerebellar Ataxia, Autosomal Recessive, 16	Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15366	UBE2W Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2W	RGD	RGD:6503620
Macaca mulatta	UBE2W	VGNC	VGNC:99479
Mus musculus	UBE2W	MGD	MGI:1914049
Others	UBE2W	NCBI

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