RNF5 - ring finger protein 5 Gene

Homo sapiens

Also known as RMA1; RING5

Gene ID: 6048 | Gene type: protein coding

About RNF5

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,178,405-32,180,793 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 185 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 45.9), small intestine (RPKM 33.9) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin Ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

RNF5 Products(1)

mRNA	Protein	Name
NM_006913.4	NP_008844.1	E3 ubiquitin-protein ligase RNF5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12861019	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	24019521	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19269966	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	19269966	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	19285439	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	19269966	GOA
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	19285439	GOA
involved in ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	24019521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF5 Protein Structure

zf-C3HC4_2

0
100
180 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF5

RING-type E3 ubiquitin transferase RNF5

RNF5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF5	Q99942	UBE2W	Homo sapiens	Q96FI0	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2W	Homo sapiens	Q96FI0	Y2H Array	25416956
Intra	RNF5	Q99942	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	RNF5	Q99942	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	25416956
Intra	RNF5	Q99942	TMEM242	Homo sapiens	Q9NWH2	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	RNF5	Q99942	UBE2E2	Homo sapiens	Q96LR5	Validated Y2H	25416956
Intra	RNF5	Q99942	UBE2E2	Homo sapiens	Q96LR5	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	25416956
Intra	RNF5	Q99942	RNF185	Homo sapiens	Q96GF1	Y2H Array	25416956
Intra	RNF5	Q99942	RNF185	Homo sapiens	Q96GF1	Anti Tag CoIP	33961781
Intra	RNF5	Q99942	RNF185	Homo sapiens	Q96GF1	Validated Y2H	25416956
Intra	RNF5	Q99942	RNF185	Homo sapiens	Q96GF1	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2D2	Homo sapiens	P62837	Y2H	14667819
Intra	RNF5	Q99942	UBE2D3	Homo sapiens	P61077	Validated Y2H	25416956
Intra	RNF5	Q99942	UBE2D3	Homo sapiens	P61077	Y2H	19549727
Intra	RNF5	Q99942	UBE2D3	Homo sapiens	P61077	Y2H Array	25416956
Intra	RNF5	Q99942	UBE2D3	Homo sapiens	P61077	Y2H Array	32296183
Intra	RNF5	Q99942	UBE2D3	Homo sapiens	P61077	Y2H	14667819
Intra	RNF5	Q99942	UBE2D3	Homo sapiens	P61077	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2D3	Homo sapiens	P61077	Y2H Array	19549727
Intra	RNF5	Q99942	UBE2E3	Homo sapiens	Q969T4	Y2H	14667819
Intra	RNF5	Q99942	UBE2E3	Homo sapiens	Q969T4	Y2H Array	31515488
Intra	RNF5	Q99942	UBE2E3	Homo sapiens	Q969T4	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2E3	Homo sapiens	Q969T4	Y2H Array	19549727
Intra	RNF5	Q99942	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	ABHD16A	Homo sapiens	O95870	Validated Y2H	25416956
Intra	RNF5	Q99942	CFTR	Homo sapiens	P13569	Anti Bait CoIP	16901789
Intra	RNF5	Q99942	SLC1A5	Homo sapiens	Q15758	Anti Tag CoIP	25759021
Intra	RNF5	Q99942	SLC1A5	Homo sapiens	Q15758	Anti Bait CoIP	25759021
Intra	RNF5	Q99942	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
Intra	RNF5	Q99942	UBE2K	Homo sapiens	P61086	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
Intra	RNF5	Q99942	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
Intra	RNF5	Q99942	UBE2K	Homo sapiens	P61086	Y2H Array	25416956
Intra	RNF5	Q99942	PXN	Homo sapiens	P49023	Anti Bait CoIP	12861019
Intra	RNF5	Q99942	PXN	Homo sapiens	P49023	Pull Down	12861019
Intra	RNF5	Q99942	RABAC1	Homo sapiens	Q9UI14	Validated Y2H	32296183
Intra	RNF5	Q99942	UBE2W	Homo sapiens	Q96B02	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2W	Homo sapiens	Q96B02	Y2H Array	19549727
Intra	RNF5	Q99942	SLC38A2	Homo sapiens	Q96QD8	Anti Tag CoIP	25759021
Intra	RNF5	Q99942	SLC38A2	Homo sapiens	Q96QD8	Anti Bait CoIP	25759021
Intra	RNF5	Q99942	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	RNF5	Q99942	UBE2D1	Homo sapiens	P51668	Validated Y2H	25416956
Intra	RNF5	Q99942	UBE2D1	Homo sapiens	P51668	Y2H	19549727
Intra	RNF5	Q99942	UBE2D1	Homo sapiens	P51668	Y2H Array	25416956
Intra	RNF5	Q99942	SLC1A1	Homo sapiens	P43005	Y2H Array	25416956
Intra	RNF5	Q99942	SLC1A1	Homo sapiens	P43005	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	RNF5	Q99942	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	25416956
Intra	RNF5	Q99942	UBTD1	Homo sapiens	Q9HAC8	Validated Y2H	32296183
Intra	RNF5	Q99942	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	RNF5	Q99942	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	RNF5	Q99942	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	RNF5	Q99942	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	25416956
Intra	RNF5	Q99942	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	RNF5	Q99942	YIPF2	Homo sapiens	Q9BWQ6	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	32296183
Intra	RNF5	Q99942	YIPF1	Homo sapiens	Q9Y548	Validated Y2H	32296183
Intra	RNF5	Q99942	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183
Intra	RNF5	Q99942	INSIG2	Homo sapiens	Q9Y5U4	Y2H Array	25416956
Intra	RNF5	Q99942	CYB561	Homo sapiens	P49447	Validated Y2H	25416956
Intra	RNF5	Q99942	CYB561	Homo sapiens	P49447	Y2H Array	25416956
Intra	RNF5	Q99942	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	25416956
Intra	RNF5	Q99942	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	25416956
Intra	RNF5	Q99942	SEC22A	Homo sapiens	Q96IW7	Y2H Array	25416956
Intra	RNF5	Q99942	RHBDD1	Homo sapiens	Q8TEB9	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Inflammatory Bowel Disease 7

IBD7

Herpes Simplex Virus Keratitis

Dendritic Keratitis	Keratitis, Dendritic
Keratitis, Herpetic

Phosphoglycerate Dehydrogenase Deficiency

Phgdh Deficiency	3-Phosphoglycerate Dehydrogenase Deficiency
PHGDHD	3-Pgdh Deficiency
3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form	Phgdh Deficiency, Infantile/Juvenile Form
Deficiency, Phosphoglycerate Dehydrogenase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123967	RNF5 inhibitor inh-02		99.81%	Unkown
HY-167673	RNF5-IN-1	Degrader	/	Unkown
HY-170515	RNF5 agonist 1	Agonist	/	Unkown
HY-RS12094	RNF5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNF5	VGNC	VGNC:76706
Bos taurus	RNF5	VGNC	VGNC:34070
Felis catus	RNF5	VGNC	VGNC:64705
Canis familiaris	RNF5	VGNC	VGNC:45673
Rattus norvegicus	RNF5	RGD	RGD:1588458
Mus musculus	RNF5	MGD	MGI:1860076
Others	RNF5	NCBI

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