2. Gene
  3. BRIX1 - biogenesis of ribosomes BRX1 Gene

BRIX1 - biogenesis of ribosomes BRX1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BRIX; BXDC2

Gene ID: 55299 | Gene type: protein coding

About BRIX1

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:34,915,711-34,925,996 (from NCBI)

This gene has 5 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in placenta (RPKM 18.1), bone marrow (RPKM 18.1) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

BRIX1 Products(1)

mRNA Protein Name
NM_018321.4 NP_060791.3 ribosome biogenesis protein BRX1 homolog
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRIX1 Protein Structure

Brix

Brix: Brix domain (64 - 243)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

ribosome biogenesis protein BRX1 homolog

BRX1, biogenesis of ribosomes, homolog

BRIX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BRIX1 Q8TDN6 EBNA1BP2 Homo sapiens Q99848
Validated Y2H
32296183
Intra
BRIX1 Q8TDN6 HNRNPU Homo sapiens Q00839
Crosslink
30021884
Intra
BRIX1 Q8TDN6 RPL13 Homo sapiens P26373
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01624 BRIX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BRIX1 RGD RGD:1308508
Felis catus BRIX1 VGNC VGNC:102167
Bos taurus BRIX1 VGNC VGNC:26569
Canis familiaris BRIX1 VGNC VGNC:38531
Macaca mulatta BRIX1 VGNC VGNC:84285
Mus musculus BRIX1 MGD MGI:1915082