COPRS - coordinator of PRMT5 and differentiation stimulator Gene

Homo sapiens

Also known as TTP1; COPR5; C17orf79; HSA272196

Gene ID: 55352 | Gene type: protein coding

About COPRS

This gene has 5 transcripts (splice variants) and 93 orthologues. Broad expression in testis (RPKM 66.1), brain (RPKM 19.5) and 22 other tissues.

Summary

Enables histone binding activity. Involved in histone H4-R3 methylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

COPRS Products(2)

mRNA	Protein	Name
NM_001330176.2	NP_001317105.1	coordinator of PRMT5 and differentiation stimulator isoform 2
NM_018405.4	NP_060875.2	coordinator of PRMT5 and differentiation stimulator isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone binding	IDA IDA: Inferred from direct assay	18404153	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18404153	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	18404153	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18404153	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPRS Protein Structure

COPR5

0
100
184 a.a.

Protein Preferred Names

Protein Names

coordinator of PRMT5 and differentiation stimulator

cooperator of PRMT5

COPRS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COPRS	Q9NQ92	H4C16	Homo sapiens	P62805	Far-WB	18404153
Intra	COPRS	Q9NQ92	H4C16	Homo sapiens	P62805	Pull Down	18404153
Intra	COPRS	Q9NQ92	PRMT5	Homo sapiens	O14744	Y2H	18404153
Intra	COPRS	Q9NQ92	PRMT5	Homo sapiens	O14744	Pull Down	18404153
Intra	COPRS	Q9NQ92	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	33961781
Intra	COPRS	Q9NQ92	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	18404153

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 17q11.2 Deletion Syndrome

Nf1 Microdeletion Syndrome	17q11 Microdeletion Syndrome
Neurofibromatosis Type 1 Microdeletion Syndrome	Van Asperen Syndrome
Del(17)(Q11)	Monosomy 17q11
Chromosome 17q11.2 Deletion Syndrome, 1.4mb

Palmoplantar Keratoderma, Bothnian Type

PPKB	Diffuse Palmoplantar Keratoderma, Bothnian Type
Bothnian Type Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Bothnian Type
Palmoplantar Keratoderma, Nonepidermolytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03026	COPRS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COPRS	RGD	RGD:1565675
Bos taurus	COPRS	VGNC	VGNC:27598
Canis familiaris	COPRS	VGNC	VGNC:55562
Macaca mulatta	COPRS	VGNC	VGNC:71367
Felis catus	COPRS	VGNC	VGNC:61086
Mus musculus	COPRS	MGD	MGI:1913673

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