2. Gene
  3. HJURP - Holliday junction recognition protein Gene

HJURP - Holliday junction recognition protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FAKTS; URLC9; hFLEG1

Gene ID: 55355 | Gene type: protein coding

About HJURP

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,836,702-233,854,535 (from NCBI)

This gene has 9 transcripts (splice variants) and 113 orthologues. Biased expression in bone marrow (RPKM 15.6), testis (RPKM 7.0) and 11 other tissues.

Summary

Enables histone binding activity and identical protein binding activity. Involved in several processes, including CENP-A containing chromatin assembly; regulation of DNA binding activity; and regulation of protein-containing complex assembly. Located in kinetochore; mitochondrion; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

HJURP Products(3)

mRNA Protein Name
NM_001282962.2 NP_001269891.1 Holliday junction recognition protein isoform b
NM_001282963.2 NP_001269892.1 Holliday junction recognition protein isoform c
NM_018410.5 NP_060880.3 Holliday junction recognition protein isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone binding IDA
IDA: Inferred from direct assay
21478274 GOA
enables histone binding IPI
IPI: Inferred from physical interaction
19410544 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
23771058 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19410544 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CENP-A containing chromatin assembly IMP
IMP: Inferred from mutant phenotype
19410544 GOA
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
19410544 GOA
involved in regulation of DNA binding IDA
IDA: Inferred from direct assay
21478274 GOA
involved in regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
21478274 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
19410544 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
19410545 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
19410545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HJURP Protein Structure

Scm3

Scm3: Centromere protein Scm3 (16 - 76)

HJURP_mid

HJURP_mid: Holliday junction recognition protein-associated repeat (271 - 386)

HJURP_C

HJURP_C: Holliday junction regulator protein family C-terminal repeat (409 - 470)

HJURP_C

HJURP_C: Holliday junction regulator protein family C-terminal repeat (554 - 614)

  • 0
  • 200
  • 400
  • 600
  • 748 a.a.
Protein Preferred Names Protein Names

Holliday junction recognition protein

14-3-3-associated AKT substrate

HJURP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Pull Down
19410544
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Anti Bait CoIP
19410545
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Anti Tag CoIP
19410545
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Confocal
19410545
Intra
HJURP Q8NCD3 CENPA Homo sapiens P49450
Pull Down
21478274
Intra
HJURP Q8NCD3 H4C16 Homo sapiens P62805
Pull Down
19410544
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
GMS
23771058
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
Anti Tag CoIP
23771058
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
Complementation
23771058
Intra
HJURP Q8NCD3 HJURP Homo sapiens Q8NCD3
Pull Down
23771058
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HJURP Proteins

Cat. No. Product Name Accession Purity
HY-P72226 HJURP Protein, Human (His-SUMO) Q8NCD3-1 (M1-V748) ≥95%

Related Diseases

Diseases Alias
Luminal Breast Carcinoma A

Breast Tumor Luminal

Luminal A Breast Carcinoma

Luminal Breast Cancer
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation

Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome

FLPIS

Scott Bryant Graham Syndrome

Craniodigital-Intellectual Disability Syndrome

Scott Craniodigital Syndrome

Scott-Bryant-Graham Syndrome

Syndactyly, Type I, With Microcephaly And Mental Retardation

Syndactyly Type I With Microcephaly And Intellectual Disability

Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly

Craniodigital Syndrome With Intellectual Disability

Craniodigital Syndrome-Intellectual Disability Syndrome

Craniodigital Syndrome-Intellectual Disability, Scott Type

Intellectual Disability-Craniodigital Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06190 HJURP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HJURP VGNC VGNC:73442
Mus musculus HJURP MGD MGI:2685821
Rattus norvegicus HJURP RGD RGD:1305846
Bos taurus HJURP VGNC VGNC:29863
Canis familiaris HJURP VGNC VGNC:41697
Felis catus HJURP VGNC VGNC:107555
Others HJURP NCBI