CENPA - centromere protein A Gene

Homo sapiens

Also known as CenH3; CENP-A

Gene ID: 1058 | Gene type: protein coding

About CENPA

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,786,056-26,794,589 (from NCBI)

This gene has 6 transcripts (splice variants), 213 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 4.5), appendix (RPKM 2.5) and 14 other tissues.

Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]

CENPA Products(2)

mRNA	Protein	Name
NM_001042426.2	NP_001035891.1	histone H3-like centromeric protein A isoform b
NM_001809.4	NP_001800.1	histone H3-like centromeric protein A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19410544	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CENP-A containing chromatin assembly	IDA IDA: Inferred from direct assay	11682612	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	19468067	GOA
involved in kinetochore assembly	IDA IDA: Inferred from direct assay	11682612	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	27499292	GOA
involved in protein localization to chromosome, centromeric region	IDA IDA: Inferred from direct assay	11682612	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CENP-A containing nucleosome	IDA IDA: Inferred from direct assay	18195732	GOA
part of CENP-A containing nucleosome	IPI IPI: Inferred from physical interaction	21743476	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	11084331	GOA
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	11682612	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27499292	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27499292	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPA Protein Structure

Histone

0
100
140 a.a.

Protein Preferred Names

Protein Names

histone H3-like centromeric protein A

centromere autoantigen A

CENPA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	X-Ray Diffraction	21478274
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	GMS	21478274
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	TAP	19410544
Intra	CENPA	P49450	H4C16	Homo sapiens	P62805	GMS	26167883
Intra	CENPA	P49450	MCM2	Homo sapiens	P49736	GMS	26167883
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	TAP	19410544
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	X-Ray Diffraction	21478274
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	GMS	21478274
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	35271311
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Density Sedimentation	19410544
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Bait CoIP	19410545
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	19410545
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Pull Down	19410545
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	26496610
Intra	CENPA	P49450	HJURP	Homo sapiens	Q8NCD3	Anti Tag CoIP	33961781
Intra	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	CENPA	P49450	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Luminal Breast Carcinoma A

Breast Tumor Luminal	Luminal A Breast Carcinoma
Luminal Breast Cancer

Crest Syndrome

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Esophageal Leukoplakia

Leukoplakia Of Esophagus

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Telangiectasis

Telangiectasia

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02473	CENPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CENPA	RGD	RGD:1563607
Mus musculus	CENPA	MGD	MGI:88375
Felis catus	CENPA	VGNC	VGNC:60752
Macaca mulatta	CENPA	VGNC	VGNC:71005
Canis familiaris	CENPA	VGNC	VGNC:39101

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