DNAJA4 - DnaJ heat shock protein family (Hsp40) member A4 Gene

Homo sapiens

Also known as MST104; MSTP104; PRO1472

Gene ID: 55466 | Gene type: protein coding

About DNAJA4

This gene has 12 transcripts (splice variants), 211 orthologues and 3 paralogues. Broad expression in heart (RPKM 43.9), testis (RPKM 33.4) and 23 other tissues.

Summary

Enables chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Apr 2022]

DNAJA4 Products(8)

mRNA	Protein	Name
NM_001130182.2	NP_001123654.1	dnaJ homolog subfamily A member 4 isoform 2
NM_001130183.2	NP_001123655.1	dnaJ homolog subfamily A member 4 isoform 3
NM_001387384.1	NP_001374313.1	dnaJ homolog subfamily A member 4 isoform 4
NM_001387385.1	NP_001374314.1	dnaJ homolog subfamily A member 4 isoform 2
NM_001387386.1	NP_001374315.1	dnaJ homolog subfamily A member 4 isoform 5
NM_001387387.1	NP_001374316.1	dnaJ homolog subfamily A member 4 isoform 6
NM_001387388.1	NP_001374317.1	dnaJ homolog subfamily A member 4 isoform 2
NM_018602.4	NP_061072.3	dnaJ homolog subfamily A member 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25036637	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21231916	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	23142051	GOA
involved in negative regulation of inclusion body assembly	IDA IDA: Inferred from direct assay	21231916	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23142051	GOA
involved in protein refolding	IDA IDA: Inferred from direct assay	21231916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
located in membrane	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJA4 Protein Structure

DnaJ

DnaJ_CXXCXGXG

DnaJ_C

0
100
200
300
397 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily A member 4

DnaJ (Hsp40) homolog, subfamily A, member 4

Related Diseases

Diseases

Alias

Plantar Wart

Verruca Plantaris	Verrucae On Sole Of Foot
Mosaic Plantar Warts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03860	DNAJA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DNAJA4	RGD	RGD:1310035
Macaca mulatta	DNAJA4	VGNC	VGNC:84334
Bos taurus	DNAJA4	VGNC	VGNC:53935
Mus musculus	DNAJA4	MGD	MGI:1927638
Felis catus	DNAJA4	VGNC	VGNC:80985
Canis familiaris	DNAJA4	VGNC	VGNC:59071

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