DNAJA2 - DnaJ heat shock protein family (Hsp40) member A2 Gene

Homo sapiens

Also known as DJ3; CPR3; DJA2; DNAJ; DNJ3; RDJ2; HIRIP4; PRO3015

Gene ID: 10294 | Gene type: protein coding

About DNAJA2

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,955,362-46,973,674 (from NCBI)

This gene has 4 transcripts (splice variants), 300 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 26.8), heart (RPKM 23.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]

DNAJA2 Products(1)

mRNA	Protein	Name
NM_005880.4	NP_005871.1	dnaJ homolog subfamily A member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	24318877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22085931	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21231916	GOA
enables unfolded protein binding	IDA IDA: Inferred from direct assay	21231916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein refolding	IDA IDA: Inferred from direct assay	21231916	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJA2 Protein Structure

DnaJ

DnaJ_CXXCXGXG

DnaJ_C

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily A member 2

DnaJ (Hsp40) homolog, subfamily A, member 2

Related Diseases

Diseases

Alias

Autoimmune Vasculitis

Subacute Bacterial Endocarditis

Endocarditis Lenta	Sbe - Subacute Bacterial Endocarditis
Subacute Endocarditis, Lenta	Endocarditis, Subacute Bacterial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03858	DNAJA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DNAJA2	MGD	MGI:1931882
Rattus norvegicus	DNAJA2	RGD	RGD:71001
Macaca mulatta	DNAJA2	VGNC	VGNC:104694

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