2. Gene
  3. PLXNA3 - plexin A3 Gene

PLXNA3 - plexin A3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as 6.3; PLXN3; PLXN4; XAP-6; HSSEXGENE

Gene ID: 55558 | Gene type: protein coding

About PLXNA3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,458,281-154,477,779 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues and 8 paralogues. Ubiquitous expression in skin (RPKM 7.2), ovary (RPKM 7.2) and 25 other tissues.

Summary

This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as Apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]

PLXNA3 Products(1)

mRNA Protein Name
NM_017514.5 NP_059984.3 plexin-A3 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20138877 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNA3 Protein Structure

Sema

Sema: Sema domain (34 - 468)

PSI

PSI: Plexin repeat (490 - 539)

PSI

PSI: Plexin repeat (637 - 684)

PSI

PSI: Plexin repeat (788 - 837)

TIG

TIG: IPT/TIG domain (840 - 926)

TIG

TIG: IPT/TIG domain (935 - 1019)

TIG

TIG: IPT/TIG domain (1023 - 1120)

TIG

TIG: IPT/TIG domain (1139 - 1201)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1293 - 1841)

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  • 1871 a.a.
Protein Preferred Names Protein Names

plexin-A3

Sex chromosome X transmembrane protein of HGF receptor family 3

PLXNA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PLXNA3 P51805 CBFA2T3 Homo sapiens O75081
Anti Tag CoIP
20138877
Intra
PLXNA3 P51805 CBFA2T3 Homo sapiens O75081
Pull Down
20138877
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10750 PLXNA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PLXNA3 VGNC VGNC:44720
Mus musculus PLXNA3 MGD MGI:107683
Macaca mulatta PLXNA3 VGNC VGNC:76185
Rattus norvegicus PLXNA3 RGD RGD:1584973
Felis catus PLXNA3 VGNC VGNC:82453