2. Gene
  3. DDX60 - DExD/H-box helicase 60 Gene

DDX60 - DExD/H-box helicase 60 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 55601 | Gene type: protein coding

About DDX60

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:168,216,294-168,325,979 (from NCBI)

This gene has 12 transcripts (splice variants), 114 orthologues and 8 paralogues. Ubiquitous expression in stomach (RPKM 14.0), colon (RPKM 7.7) and 24 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an Antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]

DDX60 Products(2)

mRNA Protein Name
NM_001410861.1 NP_001397790.1 probable ATP-dependent RNA helicase DDX60 isoform 2
NM_017631.6 NP_060101.3 probable ATP-dependent RNA helicase DDX60 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
21791617 GOA
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
21791617 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21791617 GOA
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
21791617 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of MDA-5 signaling pathway IMP
IMP: Inferred from mutant phenotype
21791617 GOA
involved in positive regulation of RIG-I signaling pathway IMP
IMP: Inferred from mutant phenotype
21791617 GOA
involved in response to virus IDA
IDA: Inferred from direct assay
21791617 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21791617 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX60 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (768 - 924)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (1261 - 1330)

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  • 1712 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX60

ATP-dependent RNA helicase DDX60

Related Diseases

Diseases Alias
Plantar Wart

Verruca Plantaris

Verrucae On Sole Of Foot

Mosaic Plantar Warts
Lip Cancer

Malignant Neoplasm Of Lip

Malignant Neoplasm Of Oral Aspect Of Lip, Not Specified Whether Upper Or Lower

Malignant Tumour Of Lip

Lip Neoplasms

Malignant Neoplasm Of Commissure Of Lip

Malignant Neoplasm Of External Lip, Not Specified As Upper Or Lower

Malignant Neoplasm Of Labial Commissure Of Lip

Malignant Neoplasm Of Lip, External

Malignant Neoplasm Of Lip, Inner Aspect

Malignant Neoplasm Of Lip, Vermilion Border

Malignant Neoplasm Of Lower Lip, Buccal Aspect

Malignant Neoplasm Of Lower Lip, Inner Aspect

Malignant Neoplasm Of Lower Lip, Mucosa

Malignant Neoplasm Of Lower Lip, Oral Aspect

Malignant Neoplasm Of Other Sites Of Lip

Malignant Neoplasm Of Vermilion Border Of Lip

Malignant Tumor Of Commissure Of Lip

Malignant Tumor Of Labial Mucosa

Malignant Tumor Of Lip

Malignant Tumor Of Lower Labial Mucosa

Malignant Tumor Of The Lip

Malignant Tumour Of Labial Commissure

Cancer Of Lip

Primary Malignant Neoplasm Of Vermilion Border Of Upper Lip

Upper Lip Cancer

Lower Lip Cancer

Primary Malignant Neoplasm Of Vermilion Border Of Lower Lip

Primary Malignant Neoplasm Of Vermilion Border Of Lip

Malignant Neoplasm Of Lipstick Area Of Upper Lip

Malignant Neoplasm Of Upper Lip Nos

Malignant Neoplasm Of Vermilion Border Of Upper Lip

Malignant Neoplasm Of Lipstick Area Of Lower Lip

Malignant Neoplasm Of Lower Lip Nos

Malignant Neoplasm Of Vermilion Border Of Lower Lip

Malignant Neoplasm Of Vermilion Border Nos

Malignant Neoplasm Of Buccal Aspect Of Upper Lip

Malignant Neoplasm Of Frenulum Of Upper Lip

Malignant Neoplasm Of Mucosa Of Upper Lip

Malignant Neoplasm Of Oral Aspect Of Upper Lip

Malignant Neoplasm Of Buccal Aspect Of Lower Lip

Malignant Neoplasm Of Frenulum Of Lower Lip

Malignant Neoplasm Of Mucosa Of Lower Lip

Malignant Neoplasm Of Oral Aspect Of Lower Lip

Malignant Neoplasm Of Buccal Aspect Of Lip, Not Specified Whether Upper Or Lower

Malignant Neoplasm Of Frenulum Of Lip, Not Specified Whether Upper Or Lower

Malignant Neoplasm Of Mucosa Of Lip, Not Specified Whether Upper Or Lower

Primary Malignant Neoplasm Of Commissure Of Lip

Primary Malignant Neoplasm Of Lip

Malignant Neoplasm Of Lip, Unspecified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03664 DDX60 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03665 DDX60L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DDX60 VGNC VGNC:71711
Mus musculus DDX60 MGD MGI:2384570
Rattus norvegicus DDX60 RGD RGD:1560014
Canis familiaris DDX60 VGNC VGNC:54938
Felis catus DDX60 VGNC VGNC:61421