EIF3E - eukaryotic translation initiation factor 3 subunit E Gene

Homo sapiens

Also known as INT6; EIF3S6; EIF3-P48; eIF3-p46

Gene ID: 3646 | Gene type: protein coding

About EIF3E

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:108,201,216-108,248,717 (from NCBI)

This gene has 57 transcripts (splice variants), 234 orthologues and is associated with 57 phenotypes. Ubiquitous expression in ovary (RPKM 226.7), lymph node (RPKM 138.2) and 25 other tissues.

Summary

Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022]

EIF3E Products(1)

mRNA	Protein	Name
NM_001568.3	NP_001559.1	eukaryotic translation initiation factor 3 subunit E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10504338	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	17468741	GOA
involved in positive regulation of mRNA binding	IPI IPI: Inferred from physical interaction	24092755	GOA
involved in positive regulation of translation	IPI IPI: Inferred from physical interaction	24092755	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	10504338	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10504338	GOA
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	9295280	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10504338	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3E Protein Structure

eIF3_N

PCI

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit E

eIF-3 p48

EIF3E Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3E	P60228	C4orf19	Homo sapiens	Q8IY42	Y2H Array	31515488
Intra	EIF3E	P60228	C4orf19	Homo sapiens	Q8IY42	Validated Y2H	25416956
Intra	EIF3E	P60228	C4orf19	Homo sapiens	Q8IY42	Y2H Array	25416956
Intra	EIF3E	P60228	ISCA2	Homo sapiens	Q86U28	Y2H Prey Pooling	32296183
Intra	EIF3E	P60228	ISCA2	Homo sapiens	Q86U28	Validated Y2H	32296183
Intra	EIF3E	P60228	ISCA2	Homo sapiens	Q86U28	Y2H Array	32296183
Intra	EIF3E	P60228	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	EIF3E	P60228	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	EIF3E	P60228	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Prey Pooling	32296183
Intra	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9-3	Validated Y2H	32296183
Intra	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Array	32296183
Intra	EIF3E	P60228	ZNF48	Homo sapiens	Q96MX3	Validated Y2H	32296183
Intra	EIF3E	P60228	ZNF48	Homo sapiens	Q96MX3	Y2H Prey Pooling	32296183
Intra	EIF3E	P60228	ZNF48	Homo sapiens	Q96MX3	Y2H Array	32296183
Intra	EIF3E	P60228	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	EIF3E	P60228	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	EIF3E	P60228	CD74	Homo sapiens	P04233	Pull Down	30833792
Intra	EIF3E	P60228	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
Intra	EIF3E	P60228	MIIP	Homo sapiens	Q5JXC2	Validated Y2H	32296183
Intra	EIF3E	P60228	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
Intra	EIF3E	P60228	DDX60	Homo sapiens	Q8IY21	Pull Down	30833792
Intra	EIF3E	P60228	MRNIP	Homo sapiens	Q6NTE8	Y2H Prey Pooling	32296183
Intra	EIF3E	P60228	MRNIP	Homo sapiens	Q6NTE8	Validated Y2H	32296183
Intra	EIF3E	P60228	MRNIP	Homo sapiens	Q6NTE8	Y2H Array	32296183
Intra	EIF3E	P60228	EIF3C	Homo sapiens	Q99613	Y2H	10504338
Intra	EIF3E	P60228	EIF3C	Homo sapiens	Q99613	Pull Down	23623729
Intra	EIF3E	P60228	EIF3C	Homo sapiens	Q99613	Anti Tag CoIP	28514442
Intra	EIF3E	P60228	EIF3D	Homo sapiens	O15371	Anti Bait CoIP	20890303
Intra	EIF3E	P60228	EIF3D	Homo sapiens	O15371	Anti Tag CoIP	33961781
Intra	EIF3E	P60228	EIF3D	Homo sapiens	O15371	Anti Tag CoIP	28514442
Intra	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	28514442
Intra	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	18599441
Intra	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	SLCA	19748344
Intra	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Pull Down	23623729
Intra	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	SLCA	18599441
Intra	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	33961781
Intra	EIF3E	P60228	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	EIF3E	P60228	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	EIF3E	P60228	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	33961781
Intra	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	28514442
Intra	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	35271311
Intra	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Pull Down	23623729
Intra	EIF3E	P60228	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Intra	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	Pull Down	23623729
Intra	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	SLCA	19748344
Intra	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	SLCA	18599441
Intra	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	Anti Tag CoIP	33961781
Intra	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	Anti Tag CoIP	28514442
Intra	EIF3E	P60228	EPAS1	Homo sapiens	Q99814	Anti Bait CoIP	17324924
Intra	EIF3E	P60228	EPAS1	Homo sapiens	Q99814	Y2H	17324924
Intra	EIF3E	P60228	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Cross	EIF3E	P60228	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034
Intra	EIF3E	P60228	TRIM27	Homo sapiens	P14373	Confocal	10504338
Intra	EIF3E	P60228	TRIM27	Homo sapiens	P14373	Y2H	10504338
Intra	EIF3E	P60228	TRIM27	Homo sapiens	P14373	Anti Tag CoIP	10504338
Intra	EIF3E	P60228	GPBP1L1	Homo sapiens	Q9HC44	Y2H Pooling	16189514
Intra	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9	Y2H Prey Pooling	25416956
Intra	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9	Y2H Pooling	16189514
Intra	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9	Validated Y2H	25416956
Intra	EIF3E	P60228	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	EIF3E	P60228	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	EIF3E	P60228	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04261	EIF3E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF3E	RGD	RGD:1311521
Felis catus	EIF3E	VGNC	VGNC:81650
Canis familiaris	EIF3E	VGNC	VGNC:40271
Macaca mulatta	EIF3E	VGNC	VGNC:83997
Mus musculus	EIF3E	MGD	MGI:99257
Bos taurus	EIF3E	VGNC	VGNC:28395

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