ASAP3 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Gene

Homo sapiens

Also known as ACAP4; UPLC1; CENTB6; DDEFL1

Gene ID: 55616 | Gene type: protein coding

About ASAP3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,428,563-23,484,631 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 114 orthologues and 28 paralogues. Ubiquitous expression in ovary (RPKM 21.1), skin (RPKM 19.0) and 23 other tissues.

Summary

This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in Cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

ASAP3 Products(2)

mRNA	Protein	Name
NM_001143778.2	NP_001137250.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform b
NM_017707.4	NP_060177.2	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	18400762	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19380743	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18400762	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	18400762	GOA
involved in regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	18400762	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	18400762	GOA
located in ruffle	IDA IDA: Inferred from direct assay	18400762	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASAP3 Protein Structure

ArfGap

Ank_2

0
200
400
600
800
903 a.a.

Protein Preferred Names

Protein Names

arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

ARF6 GTPase-activating protein

ASAP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ASAP3	Q8TDY4	UBE3A	Homo sapiens	Q05086-2	Validated Y2H	25416956
Intra	ASAP3	Q8TDY4	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	ASAP3	Q8TDY4	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	ASAP3	Q8TDY4	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	ASAP3	Q8TDY4	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	ASAP3	Q8TDY4	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	ASAP3	Q8TDY4	NHERF4	Homo sapiens	Q86UT5-3	Y2H Prey Pooling	32296183
Intra	ASAP3	Q8TDY4	NHERF4	Homo sapiens	Q86UT5-3	Y2H Array	32296183
Intra	ASAP3	Q8TDY4	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	ASAP3	Q8TDY4	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	ASAP3	Q8TDY4	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	ASAP3	Q8TDY4	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	ASAP3	Q8TDY4	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	ASAP3	Q8TDY4	NHERF4	Homo sapiens	Q86UT5	Validated Y2H	25416956
Intra	ASAP3	Q8TDY4	NHERF4	Homo sapiens	Q86UT5	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01057	ASAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ASAP3	VGNC	VGNC:99849
Rattus norvegicus	ASAP3	RGD	RGD:1593929
Mus musculus	ASAP3	MGD	MGI:2684986
Bos taurus	ASAP3	VGNC	VGNC:54406
Felis catus	ASAP3	VGNC	VGNC:59954

Name
Email *

	Sorry, but the email address you supplied was invalid.