LYAR - Ly1 antibody reactive Gene

Homo sapiens

Also known as ZLYAR; ZC2HC2

Gene ID: 55646 | Gene type: protein coding

About LYAR

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:4,267,701-4,290,154 (from NCBI)

This gene has 4 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 46.8), lymph node (RPKM 8.5) and 20 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor binding activity; identical protein binding activity; and transcription regulator inhibitor activity. Involved in several processes, including erythrocyte development; negative regulation of innate immune response; and regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LYAR Products(2)

mRNA	Protein	Name
NM_001145725.2	NP_001139197.1	cell growth-regulating nucleolar protein
NM_017816.3	NP_060286.1	cell growth-regulating nucleolar protein

LYAR Protein Structure

zf-LYAR

0
100
200
300
379 a.a.

Protein Preferred Names

Protein Names

cell growth-regulating nucleolar protein

Ly1 antibody reactive homolog

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07909	LYAR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LYAR	RGD	RGD:1305352
Felis catus	LYAR	VGNC	VGNC:63336
Mus musculus	LYAR	MGD	MGI:107470
Bos taurus	LYAR	VGNC	VGNC:31095
Macaca mulatta	LYAR	VGNC	VGNC:74364
Canis familiaris	LYAR	VGNC	VGNC:42879

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