RNF126 - ring finger protein 126 Gene

Homo sapiens

Gene ID: 55658 | Gene type: protein coding

About RNF126

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:647,526-663,214 (from NCBI)

This gene has 7 transcripts (splice variants), 262 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.1), spleen (RPKM 11.1) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

RNF126 Products(2)

mRNA	Protein	Name
NM_001366018.1	NP_001352947.1	E3 ubiquitin-protein ligase RNF126 isoform 2
NM_194460.3	NP_919442.1	E3 ubiquitin-protein ligase RNF126 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	23026136	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasm protein quality control by the ubiquitin-proteasome system	IMP IMP: Inferred from mutant phenotype	24981174	GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23418353	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	36563124	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24981174	GOA
involved in protein K27-linked ubiquitination	IDA IDA: Inferred from direct assay	36563124	GOA
involved in protein K29-linked ubiquitination	IDA IDA: Inferred from direct assay	36563124	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	23277564	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23026136	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	24275455	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24981174	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23026136	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	23418353	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23026136	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23026136	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF126 Protein Structure

zinc_ribbon_9

zf-RING_2

0
100
200
311 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF126

RNF126 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF126	Q9BV68	BAG6	Homo sapiens	P46379-2	Anti Tag CoIP	28514442
Intra	RNF126	Q9BV68	BAG6	Homo sapiens	P46379	Anti Tag CoIP	33961781
Intra	RNF126	Q9BV68	BAG6	Homo sapiens	P46379	Y2H Array	25416956
Intra	RNF126	Q9BV68	UBE2D1	Homo sapiens	P51668	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Friedreich Ataxia

Friedreich Ataxia 1	FRDA
Friedreich Ataxia With Retained Reflexes	Frda1
Fa	Friedreich'S Ataxia
Hereditary Spinal Ataxia	Fa1
Friedreich'S Tabes	Hereditary Spinal Sclerosis
Spinocerebellar Ataxia, Friedreich	Friedreich Spinocerebellar Ataxia
Friedrich'S Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163639	BRD4 degrader-2	Inhibitor	/	Unkown
HY-170574	CQ627		/	Unkown
HY-RS12045	RNF126 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RNF126	VGNC	VGNC:34018
Canis familiaris	RNF126	VGNC	VGNC:84866
Rattus norvegicus	RNF126	RGD	RGD:1306011
Mus musculus	RNF126	MGD	MGI:1917544
Felis catus	RNF126	VGNC	VGNC:102685
Macaca mulatta	RNF126	VGNC	VGNC:76791

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