2. Gene
  3. SLC30A6 - solute carrier family 30 member 6 Gene

SLC30A6 - solute carrier family 30 member 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZNT6; MST103; MSTP103

Gene ID: 55676 | Gene type: protein coding

About SLC30A6

Cytogenetic location: 2p22.3 Genomic coordinates (GRCh38): 2:32,165,864-32,224,379 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 4.9), urinary bladder (RPKM 4.1) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]

SLC30A6 Products(8)

mRNA Protein Name
NM_001193513.3 NP_001180442.1 zinc transporter 6 isoform 1
NM_001193514.3 NP_001180443.1 zinc transporter 6 isoform 3
NM_001193515.3 NP_001180444.1 zinc transporter 6 isoform 4
NM_001330476.2 NP_001317405.1 zinc transporter 6 isoform 5
NM_001330477.2 NP_001317406.1 zinc transporter 6 isoform 6
NM_001330478.2 NP_001317407.1 zinc transporter 6 isoform 6
NM_001330479.2 NP_001317408.1 zinc transporter 6 isoform 7
NM_017964.5 NP_060434.2 zinc transporter 6 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15994300 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
15994300 GOA
NOT enables zinc:proton antiporter activity IDA
IDA: Inferred from direct assay
19366695 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of zinc ion transport IDA
IDA: Inferred from direct assay
19366695 GOA
involved in zinc ion import into Golgi lumen IDA
IDA: Inferred from direct assay
15994300 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17349999 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
19366695 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A6 Protein Structure

Cation_efflux

Cation_efflux: Cation efflux family (35 - 331)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

zinc transporter 6

solute carrier family 30 (zinc transporter), member 6

SLC30A6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC30A6 Q6NXT4 SLC30A5 Homo sapiens Q8TAD4
Anti Tag CoIP
19759014
Intra
SLC30A6 Q6NXT4 SLC30A5 Homo sapiens Q8TAD4
IF
19759014
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypermanganesemia With Dystonia 1

Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis

HMNDYT1

Hmdpc

Hypermanganesemia With Dystonia Polycythemia And Cirrhosis

Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease

Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Hypermanganesemia With Dystonia 2

HMNDYT2

Dystonia-Parkinsonism-Hypermanganesemia Syndrome

Hypermanganesemia With Dystonia, Type 2
Spastic Paraplegia 4, Autosomal Dominant

SPG4

Hereditary Spastic Paraplegia 4

Fsp2

Autosomal Dominant Spastic Paraplegia Type 4

Familial Spastic Paraplegia, Autosomal Dominant, 2

Autosomal Dominant Spastic Paraplegia 4

Familial Spastic Paraplegia Autosomal Dominant 2

Paraplegia, Spastic, Autosomal Dominant, Type 4
Hypermanganesemia With Dystonia

Familial Manganese-Induced Neurotoxicity

Hmndyt
Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13184 SLC30A6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC30A6 MGD MGI:2386741
Macaca mulatta SLC30A6 VGNC VGNC:77513
Rattus norvegicus SLC30A6 RGD RGD:1309250
Felis catus SLC30A6 VGNC VGNC:65312
Bos taurus SLC30A6 VGNC VGNC:34810
Canis familiaris SLC30A6 VGNC VGNC:46351