RBM22 - RNA binding motif protein 22 Gene

Homo sapiens

Also known as Cwc2; ZC3H16; fSAP47

Gene ID: 55696 | Gene type: protein coding

About RBM22

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,690,792-150,701,062 (from NCBI)

This gene has 8 transcripts (splice variants) and 235 orthologues. Ubiquitous expression in bone marrow (RPKM 24.5), lymph node (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

RBM22 Products(1)

mRNA	Protein	Name
NM_018047.3	NP_060517.1	pre-mRNA-splicing factor RBM22

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables U6 snRNA binding	IDA IDA: Inferred from direct assay	22246180	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	17045351	GOA
enables pre-mRNA binding	IDA IDA: Inferred from direct assay	22246180	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	21122810	GOA
involved in mRNA cis splicing, via spliceosome	IDA IDA: Inferred from direct assay	22246180	GOA
involved in positive regulation of RNA splicing	IDA IDA: Inferred from direct assay	22246180	GOA
involved in positive regulation of protein export from nucleus	IDA IDA: Inferred from direct assay	21122810	GOA
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	21122810	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21122810	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17045351	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM22 Protein Structure

RRM_1

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

pre-mRNA-splicing factor RBM22

functional spliceosome-associated protein 47

RBM22 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBM22	Q9NW64	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	RBM22	Q9NW64	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	RBM22	Q9NW64	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	RBM22	Q9NW64	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	RBM22	Q9NW64	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	RBM22	Q9NW64	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	RBM22	Q9NW64	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	RBM22	Q9NW64	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	25416956
Intra	RBM22	Q9NW64	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	RBM22	Q9NW64	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	RBM22	Q9NW64	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	RBM22	Q9NW64	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	RBM22	Q9NW64	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
Intra	RBM22	Q9NW64	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia

Pch	Congenital Pontocerebellar Hypoplasia
Opch	Hypoplasia, Pontocerebellar
Pontoneocerebellar Hypoplasia	Nonsyndromic Pontocerebellar Hypoplasia

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11740	RBM22 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RBM22	MGD	MGI:1914060
Rattus norvegicus	RBM22	RGD	RGD:1305770
Macaca mulatta	RBM22	VGNC	VGNC:76535
Canis familiaris	RBM22	VGNC	VGNC:45415
Felis catus	RBM22	VGNC	VGNC:64525
Bos taurus	RBM22	VGNC	VGNC:33792

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