GIGYF1 - GRB10 interacting GYF protein 1 Gene

Homo sapiens

Also known as GYF1; PERQ1

Gene ID: 64599 | Gene type: protein coding

About GIGYF1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,679,507-100,694,250 (from NCBI)

This gene has 7 transcripts (splice variants), 226 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 15.6), endometrium (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a member of the gyf family of adaptor proteins. The encoded protein contains a gyf protein interaction domain. It binds growth factor receptor bound 10, another adaptor protein that binds activated insulin-like growth factor 1 and Insulin receptors and regulates receptor signaling. [provided by RefSeq, Apr 2017]

GIGYF1 Products(10)

mRNA	Protein	Name
NM_001375759.1	NP_001362688.1	GRB10-interacting GYF protein 1 isoform a
NM_001375760.1	NP_001362689.1	GRB10-interacting GYF protein 1 isoform a
NM_001375761.1	NP_001362690.1	GRB10-interacting GYF protein 1 isoform a
NM_001375762.1	NP_001362691.1	GRB10-interacting GYF protein 1 isoform a
NM_001375763.1	NP_001362692.1	GRB10-interacting GYF protein 1 isoform a
NM_001375764.1	NP_001362693.1	GRB10-interacting GYF protein 1 isoform a
NM_001375765.1	NP_001362694.1	GRB10-interacting GYF protein 1 isoform b
NM_001375766.1	NP_001362695.1	GRB10-interacting GYF protein 1 isoform b
NM_001375767.1	NP_001362696.1	GRB10-interacting GYF protein 1 isoform c
NM_001375768.1	NP_001362697.1	GRB10-interacting GYF protein 1 isoform d

GIGYF1 Protein Structure

GYF

0
200
400
600
800
1035 a.a.

Protein Preferred Names

Protein Names

GRB10-interacting GYF protein 1

PERQ amino acid-rich with GYF domain-containing protein 1

Related Diseases

Diseases

Alias

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05421	GIGYF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GIGYF1	VGNC	VGNC:68924
Canis familiaris	GIGYF1	VGNC	VGNC:41213
Rattus norvegicus	GIGYF1	RGD	RGD:1309933
Bos taurus	GIGYF1	VGNC	VGNC:29355
Mus musculus	GIGYF1	MGD	MGI:1888677
Macaca mulatta	GIGYF1	VGNC	VGNC:73158

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