2. Gene
  3. GIGYF1 - GRB10 interacting GYF protein 1 Gene

GIGYF1 - GRB10 interacting GYF protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GYF1; PERQ1

Gene ID: 64599 | Gene type: protein coding

About GIGYF1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,679,507-100,694,250 (from NCBI)

This gene has 7 transcripts (splice variants), 226 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 15.6), endometrium (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a member of the gyf family of adaptor proteins. The encoded protein contains a gyf protein interaction domain. It binds growth factor receptor bound 10, another adaptor protein that binds activated insulin-like growth factor 1 and Insulin receptors and regulates receptor signaling. [provided by RefSeq, Apr 2017]

GIGYF1 Products(10)

mRNA Protein Name
NM_001375759.1 NP_001362688.1 GRB10-interacting GYF protein 1 isoform a
NM_001375760.1 NP_001362689.1 GRB10-interacting GYF protein 1 isoform a
NM_001375761.1 NP_001362690.1 GRB10-interacting GYF protein 1 isoform a
NM_001375762.1 NP_001362691.1 GRB10-interacting GYF protein 1 isoform a
NM_001375763.1 NP_001362692.1 GRB10-interacting GYF protein 1 isoform a
NM_001375764.1 NP_001362693.1 GRB10-interacting GYF protein 1 isoform a
NM_001375765.1 NP_001362694.1 GRB10-interacting GYF protein 1 isoform b
NM_001375766.1 NP_001362695.1 GRB10-interacting GYF protein 1 isoform b
NM_001375767.1 NP_001362696.1 GRB10-interacting GYF protein 1 isoform c
NM_001375768.1 NP_001362697.1 GRB10-interacting GYF protein 1 isoform d

GIGYF1 Protein Structure

GYF

GYF: GYF domain (476 - 529)

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  • 1035 a.a.
Protein Preferred Names Protein Names

GRB10-interacting GYF protein 1

PERQ amino acid-rich with GYF domain-containing protein 1

GIGYF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GIGYF1 O75420 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
GIGYF1 O75420 TSHZ2 Homo sapiens Q9NRE2
Validated Y2H
32296183
Intra
GIGYF1 O75420 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra
GIGYF1 O75420 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
GIGYF1 O75420 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
GIGYF1 O75420 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
GIGYF1 O75420 PRR35 Homo sapiens P0CG20
Validated Y2H
32296183
Intra
GIGYF1 O75420 PRR35 Homo sapiens P0CG20
Y2H Prey Pooling
32296183
Intra
GIGYF1 O75420 FAM124B Homo sapiens Q9H5Z6-2
Validated Y2H
32296183
Intra
GIGYF1 O75420 ANKRD10 Homo sapiens Q9NXR5-2
Validated Y2H
32296183
Intra
GIGYF1 O75420 PRKAA2 Homo sapiens P54646
Validated Y2H
32296183
Intra
GIGYF1 O75420 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
GIGYF1 O75420 TROAP Homo sapiens Q12815
Validated Y2H
32296183
Intra
GIGYF1 O75420 RBM22 Homo sapiens Q9NW64
Validated Y2H
32296183
Intra
GIGYF1 O75420 EIF4E2 Homo sapiens O60573-1
ITC
28698298
Intra
GIGYF1 O75420 EIF4E2 Homo sapiens O60573-1
Anti Tag CoIP
28698298
Intra
GIGYF1 O75420 EIF4E2 Homo sapiens O60573-1
Pull Down
28698298
Intra
GIGYF1 O75420 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
GIGYF1 O75420 DDX6 Homo sapiens P26196
Anti Tag CoIP
33961781
Intra
GIGYF1 O75420 DDX6 Homo sapiens P26196
Validated Y2H
32296183
Intra
GIGYF1 O75420 DYNC1H1 Homo sapiens Q14204
Anti Bait CoIP
36950384
Intra
GIGYF1 O75420 SMARCC2 Homo sapiens Q8TAQ2
Anti Bait CoIP
36950384
Intra
GIGYF1 O75420 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
GIGYF1 O75420 SNRPB Homo sapiens P14678-2
Validated Y2H
32296183
Intra
GIGYF1 O75420 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
GIGYF1 O75420 SNRPA Homo sapiens P09012
Validated Y2H
32296183
Intra
GIGYF1 O75420 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
Intra
GIGYF1 O75420 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
GIGYF1 O75420 ZNF598 Homo sapiens Q86UK7
Anti Tag CoIP
33053355
Intra
GIGYF1 O75420 ZNF598 Homo sapiens Q86UK7
Anti Tag CoIP
33961781
Intra
GIGYF1 O75420 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
32296183
Intra
GIGYF1 O75420 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra
GIGYF1 O75420 MNS1 Homo sapiens Q8NEH6
Validated Y2H
32296183
Intra
GIGYF1 O75420 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
GIGYF1 O75420 STAC3 Homo sapiens Q96MF2
Validated Y2H
32296183
Intra
GIGYF1 O75420 STAC3 Homo sapiens Q96MF2
Anti Bait CoIP
36950384
Intra
GIGYF1 O75420 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
32296183
Intra
GIGYF1 O75420 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
GIGYF1 O75420 SNRPC Homo sapiens P09234
Validated Y2H
32296183
Intra
GIGYF1 O75420 SCAF8 Homo sapiens Q9UPN6
Validated Y2H
32296183
Intra
GIGYF1 O75420 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05421 GIGYF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GIGYF1 VGNC VGNC:68924
Canis familiaris GIGYF1 VGNC VGNC:41213
Rattus norvegicus GIGYF1 RGD RGD:1309933
Bos taurus GIGYF1 VGNC VGNC:29355
Mus musculus GIGYF1 MGD MGI:1888677
Macaca mulatta GIGYF1 VGNC VGNC:73158