CCAR1 - cell division cycle and apoptosis regulator 1 Gene

Homo sapiens

Gene ID: 55749 | Gene type: protein coding

About CCAR1

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:68,721,239-68,792,377 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 17.5), appendix (RPKM 15.2) and 25 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Apr 2022]

CCAR1 Products(3)

mRNA	Protein	Name
NM_001282959.2	NP_001269888.1	cell division cycle and apoptosis regulator protein 1 isoform b
NM_001282960.2	NP_001269889.1	cell division cycle and apoptosis regulator protein 1 isoform b
NM_018237.4	NP_060707.2	cell division cycle and apoptosis regulator protein 1 isoform a

CCAR1 Protein Structure

S1-like

DBC1

SAP

0
200
400
600
800
1000
1150 a.a.

Protein Preferred Names

Protein Names

cell division cycle and apoptosis regulator protein 1

cell cycle and apoptosis regulatory protein 1

CCAR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCAR1	Q8IX12	DNAAF6	Homo sapiens	Q9NQM4	Y2H Prey Pooling	25416956
Intra	CCAR1	Q8IX12	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CCAR1	Q8IX12	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CCAR1	Q8IX12	TRIM63	Homo sapiens	Q969Q1	Y2H	18157088
Intra	CCAR1	Q8IX12	TRIM63	Homo sapiens	Q969Q1	Pull Down	18157088
Intra	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CCAR1	Q8IX12	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CCAR1	Q8IX12	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	20594350

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Drug-Induced Lupus Erythematosus

Dile	Dil
Drug-Induced Systemic Lupus Erythematosus

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119331	CFM-5	Inducer	/	Unkown
HY-RS02020	CCAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCAR1	RGD	RGD:1560358
Mus musculus	CCAR1	MGD	MGI:1914750
Felis catus	CCAR1	VGNC	VGNC:60442
Bos taurus	CCAR1	VGNC	VGNC:106671
Macaca mulatta	CCAR1	VGNC	VGNC:97743
Canis familiaris	CCAR1	VGNC	VGNC:38773

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