WWTR1 - WW domain containing transcription regulator 1 Gene

Homo sapiens

Also known as TAZ

Gene ID: 25937 | Gene type: protein coding

About WWTR1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,517,235-149,724,788 (from NCBI)

This gene has 12 transcripts (splice variants), 160 orthologues, 1 paralogue and is associated with 64 phenotypes. Ubiquitous expression in gall bladder (RPKM 24.8), endometrium (RPKM 22.7) and 24 other tissues.

Summary

Enables transcription coactivator activity. Involved in several processes, including hippo signaling; positive regulation of cell differentiation; and regulation of signal transduction. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

WWTR1 Products(4)

mRNA	Protein	Name
NM_001168278.3	NP_001161750.1	WW domain-containing transcription regulator protein 1
NM_001168280.3	NP_001161752.1	WW domain-containing transcription regulator protein 1
NM_001348362.2	NP_001335291.1	WW domain-containing transcription regulator protein 1
NM_015472.6	NP_056287.1	WW domain-containing transcription regulator protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16099986	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19010321	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	23911299	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	19010321	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	18568018	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	18227151	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	29496737	GOA
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20412773	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18227151	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18227151	GOA
involved in positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	29496737	GOA
involved in stem cell division	IDA IDA: Inferred from direct assay	18568018	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20412773	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	19010321	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18568018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WWTR1 Protein Structure

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

WW domain-containing transcription regulator protein 1

transcriptional co-activator with PDZ-binding motif

WWTR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WWTR1	Q9GZV5	TCP11L1	Homo sapiens	Q9NUJ3	Validated Y2H	32296183
Intra	WWTR1	Q9GZV5	BTRC	Homo sapiens	Q9Y297	Anti Tag CoIP	33961781
Intra	WWTR1	Q9GZV5	CCAR1	Homo sapiens	Q8IX12	Anti Bait CoIP	20594350
Intra	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
Intra	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	CoIP	16099986
Intra	WWTR1	Q9GZV5	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	WWTR1	Q9GZV5	SCRIB	Homo sapiens	Q14160	Anti Bait CoIP	22078877
Intra	WWTR1	Q9GZV5	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	33961781
Intra	WWTR1	Q9GZV5	LATS1	Homo sapiens	O95835	Anti Bait CoIP	22078877
Intra	WWTR1	Q9GZV5	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	23245942
Intra	WWTR1	Q9GZV5	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	22234184
Intra	WWTR1	Q9GZV5	DVL1	Homo sapiens	O14640	Lumier	20412773
Intra	WWTR1	Q9GZV5	WBP2	Homo sapiens	Q969T9	Anti Tag CoIP	20972459
Intra	WWTR1	Q9GZV5	WBP2	Homo sapiens	Q969T9	Pull Down	20972459
Intra	WWTR1	Q9GZV5	DVL2	Homo sapiens	O14641	Lumier	20412773
Intra	WWTR1	Q9GZV5	DVL2	Homo sapiens	O14641	Anti Bait CoIP	20412773
Intra	WWTR1	Q9GZV5	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	28514442
Intra	WWTR1	Q9GZV5	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epithelioid Hemangioendothelioma

Hemangioendothelioma Epithelioid

Epithelioid Hemangioendothelioma, Malignant

Malignant Epithelioid Hemangioendothelioma

Epithelioid Hemangioendothelioma, Malignant

Histiocytoid Hemangioma

Angiolymphoid Hyperplasia With Eosinophilia	Epithelioid Haemangioma
Epithelioid Hemangioma

Hemangioendothelioma

Malignant Hemangioma

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Eccrine Acrospiroma

Acrospiroma	Poroma
Eccrine Hidradenoma	Eccrine Hidradenoma Of Skin
Hidradenoma	Adenoma, Sweat Gland
Benign Neoplasm Of Sweat Gland	Eccrine Poroma

Eccrine Sweat Gland Neoplasm

Eccrine Skin Neoplasm	Eccrine Tumor
Eccrine Neoplasm	Malignant Eccrine Neoplasm

Choroid Plexus Meningioma

Choroid Meningioma

Meningioma Of The Choroid Plexus

Eccrine Porocarcinoma

Porocarcinoma	Eccrine Porocarcinoma Of Skin
Malignant Eccrine Poroma

Eccrine Sweat Gland Cancer

Malignant Eccrine Skin Neoplasm

Malignant Eccrine Tumor

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Childhood Angiosarcoma

Paediatric Angiosarcoma	Paediatric Hemangiosarcoma
Pediatric Angiosarcoma	Pediatric Hemangiosarcoma

Vascular Cancer

Blood Vessel Tumors	Malignant Vascular Neoplasm
Renal Vein Leiomyosarcoma	Vascular Neoplasms
Blood Vessel Neoplasm	Blood Vessel Tumor
Blood Vessel Tumour Disorder	Haemangiomatous Tumour
Leiomyosarcoma Of The Renal Vein	Malignant Great Vessel Tumor
Malignant Tumor Of Pulmonary Artery	Malignant Tumor Of Pulmonary Vein
Malignant Vascular Tumor	Neoplasm Of Great Vessel
Pulmonary Artery Malignant Neoplasm	Pulmonary Vein Malignant Neoplasm
Vascular Tissue Neoplasm	Vascular Tumors
Blood Vessel Cancer	Neoplasms, Vascular Tissue
Malignant Neoplasm Of Great Vessels

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Rhabdomyosarcoma

Sclerosing Hepatic Carcinoma

Sclerosing Hepatocellular Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16236	Wwtr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15862	WWTR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WWTR1	RGD	RGD:1559609
Mus musculus	WWTR1	MGD	MGI:1917649
Canis familiaris	WWTR1	VGNC	VGNC:52910
Macaca mulatta	WWTR1	VGNC	VGNC:79415
Felis catus	WWTR1	VGNC	VGNC:102868
Bos taurus	WWTR1	VGNC	VGNC:36980

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