FOXJ2 - forkhead box J2 Gene

Homo sapiens

Also known as FHX

Gene ID: 55810 | Gene type: protein coding

About FOXJ2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,032,716-8,055,517 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues and 42 paralogues. Ubiquitous expression in endometrium (RPKM 8.4), ovary (RPKM 8.2) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FOXJ2 Products(1)

mRNA	Protein	Name
NM_018416.3	NP_060886.1	forkhead box protein J2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10777590	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10777590	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25609649	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10777590	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	24792364	GOA
involved in negative regulation of blood vessel endothelial cell differentiation	IDA IDA: Inferred from direct assay	24792364	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10777590	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10777590	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	24792364	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24792364	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXJ2 Protein Structure

Forkhead

0
100
200
300
400
500
574 a.a.

Protein Preferred Names

Protein Names

forkhead box protein J2

FOXJ2 forkhead factor

FOXJ2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXJ2	Q9P0K8	EGLN3	Homo sapiens	Q9H6Z9	Y2H Prey Pooling	25416956
Intra	FOXJ2	Q9P0K8	EGLN3	Homo sapiens	Q9H6Z9	Validated Y2H	25416956
Intra	FOXJ2	Q9P0K8	EYA4	Homo sapiens	O95677	TAP	25609649
Intra	FOXJ2	Q9P0K8	DLX5	Homo sapiens	P56178	TAP	25609649
Intra	FOXJ2	Q9P0K8	FOXF2	Homo sapiens	Q12947	TAP	25609649
Intra	FOXJ2	Q9P0K8	BBX	Homo sapiens	Q8WY36	TAP	25609649
Intra	FOXJ2	Q9P0K8	FOXC1	Homo sapiens	Q12948	TAP	25609649
Intra	FOXJ2	Q9P0K8	ADNP	Homo sapiens	Q9H2P0	TAP	25609649
Intra	FOXJ2	Q9P0K8	ESS2	Homo sapiens	Q96DF8	TAP	25609649
Intra	FOXJ2	Q9P0K8	EMSY	Homo sapiens	Q7Z589	TAP	25609649
Intra	FOXJ2	Q9P0K8	CUX1	Homo sapiens	P39880	TAP	25609649
Intra	FOXJ2	Q9P0K8	AKAP8	Homo sapiens	O43823	TAP	25609649
Intra	FOXJ2	Q9P0K8	CSTF2T	Homo sapiens	Q9H0L4	Validated Y2H	32296183
Intra	FOXJ2	Q9P0K8	FOXJ2	Homo sapiens	Q9P0K8	TAP	25609649
Intra	FOXJ2	Q9P0K8	DNTTIP1	Homo sapiens	Q9H147	TAP	25609649
Intra	FOXJ2	Q9P0K8	CHD4	Homo sapiens	Q14839	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05057	FOXJ2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FOXJ2	VGNC	VGNC:62337
Macaca mulatta	FOXJ2	VGNC	VGNC:72568
Bos taurus	FOXJ2	VGNC	VGNC:29090
Rattus norvegicus	FOXJ2	RGD	RGD:1565101
Canis familiaris	FOXJ2	VGNC	VGNC:40955
Mus musculus	FOXJ2	MGD	MGI:1926805

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