AKAP8 - A-kinase anchoring protein 8 Gene

Homo sapiens

Also known as AKAP-8; AKAP95; AKAP 95; AKAP-95

Gene ID: 10270 | Gene type: protein coding

About AKAP8

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,353,385-15,379,787 (from NCBI)

This gene has 12 transcripts (splice variants), 118 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 13.0), spleen (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and Other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

AKAP8 Products(1)

mRNA	Protein	Name
NM_005858.4	NP_005849.1	A-kinase anchor protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	16980585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9473338	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell cycle G2/M phase transition	IMP IMP: Inferred from mutant phenotype	16980585	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	26683827	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP8 Protein Structure

AKAP95

0
200
400
600
692 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 8

A kinase (PRKA) anchor protein 8

AKAP8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKAP8	O43823	PRKAR2A	Homo sapiens	P13861	IF	9473338
Intra	AKAP8	O43823	PRKAR2A	Homo sapiens	P13861	Anti Bait CoIP	9473338
Intra	AKAP8	O43823	PRKAR2A	Homo sapiens	P13861	Far-WB	9473338
Intra	AKAP8	O43823	MCM2	Homo sapiens	P49736	Pull Down	12740381
Intra	AKAP8	O43823	MCM2	Homo sapiens	P49736	Anti Bait CoIP	12740381
Intra	AKAP8	O43823	MCM2	Homo sapiens	P49736	Y2H	12740381
Intra	AKAP8	O43823	CASP3	Homo sapiens	P42574	Anti Bait CoIP	16227597
Intra	AKAP8	O43823	ASH2L	Homo sapiens	Q9UBL3	Pull Down	23995757
Intra	AKAP8	O43823	ASH2L	Homo sapiens	Q9UBL3	Anti Tag CoIP	23995757
Intra	AKAP8	O43823	ASH2L	Homo sapiens	Q9UBL3	GMS	23995757
Intra	AKAP8	O43823	WDR5	Homo sapiens	P61964	Pull Down	23995757
Intra	AKAP8	O43823	WDR5	Homo sapiens	P61964	Anti Tag CoIP	23995757
Intra	AKAP8	O43823	WDR5	Homo sapiens	P61964	GMS	23995757
Intra	AKAP8	O43823	HDAC3	Homo sapiens	O15379	GMS	16980585
Intra	AKAP8	O43823	HDAC3	Homo sapiens	O15379	Anti Tag CoIP	16980585
Intra	AKAP8	O43823	MYCBP	Homo sapiens	Q99417	Y2H	12740381
Intra	AKAP8	O43823	DPY30	Homo sapiens	Q9C005	GMS	23995757
Intra	AKAP8	O43823	RPS6KA1	Homo sapiens	Q15418	Anti Bait CoIP	22130794
Intra	AKAP8	O43823	RPS6KA1	Homo sapiens	Q15418	IF	22130794

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00523	AKAP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00524	AKAP8L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKAP8	RGD	RGD:620832
Canis familiaris	AKAP8	VGNC	VGNC:37761
Felis catus	AKAP8	VGNC	VGNC:59718
Macaca mulatta	AKAP8	VGNC	VGNC:108459
Mus musculus	AKAP8	MGD	MGI:1928488
Bos taurus	AKAP8	VGNC	VGNC:25789

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