2. Gene
  3. AKAP8 - A-kinase anchoring protein 8 Gene

AKAP8 - A-kinase anchoring protein 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as AKAP-8; AKAP95; AKAP 95; AKAP-95

Gene ID: 10270 | Gene type: protein coding

About AKAP8

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,353,385-15,379,787 (from NCBI)

This gene has 12 transcripts (splice variants), 118 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 13.0), spleen (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

AKAP8 Products(1)

mRNA Protein Name
NM_005858.4 NP_005849.1 A-kinase anchor protein 8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
16980585 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9473338 GOA
enables protein kinase A regulatory subunit binding IPI
IPI: Inferred from physical interaction
17911601 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell cycle G2/M phase transition IMP
IMP: Inferred from mutant phenotype
16980585 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleolus IDA
IDA: Inferred from direct assay
26683827 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP8 Protein Structure

AKAP95

AKAP95: A-kinase anchoring protein 95 (AKAP95) (390 - 551)

  • 0
  • 200
  • 400
  • 600
  • 692 a.a.
Protein Preferred Names Protein Names

A-kinase anchor protein 8

A kinase (PRKA) anchor protein 8

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00523 AKAP8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00524 AKAP8L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKAP8 RGD RGD:620832
Canis familiaris AKAP8 VGNC VGNC:37761
Felis catus AKAP8 VGNC VGNC:59718
Macaca mulatta AKAP8 VGNC VGNC:108459
Mus musculus AKAP8 MGD MGI:1928488
Bos taurus AKAP8 VGNC VGNC:25789