DNTTIP1 - deoxynucleotidyltransferase terminal interacting protein 1 Gene

Homo sapiens

Also known as Tdif1; C20orf167; dJ447F3.4

Gene ID: 116092 | Gene type: protein coding

About DNTTIP1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,791,954-45,811,418 (from NCBI)

This gene has 6 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 14.1), bone marrow (RPKM 12.1) and 25 other tissues.

Summary

DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA Polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]

DNTTIP1 Products(1)

mRNA	Protein	Name
NM_052951.3	NP_443183.1	deoxynucleotidyltransferase terminal-interacting protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11473582	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	25653165	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11473582	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11473582	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	25653165	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11473582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

deoxynucleotidyltransferase terminal-interacting protein 1

TdT binding protein

DNTTIP1 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DNTTIP1	Q9H147	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	DNTTIP1	Q9H147	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	DNTTIP1	Q9H147	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	DNTTIP1	Q9H147	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	DNTTIP1	Q9H147	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	DNTTIP1	Q9H147	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	DNTTIP1	Q9H147	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	DNTTIP1	Q9H147	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lymph Node Carcinoma

Lymph Node Cancer	Lymph Node Neoplasm
Neoplasm Of Lymph Node

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS03917	DNTTIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DNTTIP1	VGNC	VGNC:40040
Rattus norvegicus	DNTTIP1	RGD	RGD:621627
Felis catus	DNTTIP1	VGNC	VGNC:61566
Macaca mulatta	DNTTIP1	VGNC	VGNC:71845
Mus musculus	DNTTIP1	MGD	MGI:1923483
Bos taurus	DNTTIP1	VGNC	VGNC:28151

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