UTP6 - UTP6 small subunit processome component Gene

Homo sapiens

Also known as HCA66; C17orf40

Gene ID: 55813 | Gene type: protein coding

About UTP6

This gene has 9 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in lymph node (RPKM 15.1), testis (RPKM 14.9) and 25 other tissues.

Summary

Predicted to enable snoRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

UTP6 Products(1)

mRNA	Protein	Name
NM_018428.3	NP_060898.2	U3 small nucleolar RNA-associated protein 6 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UTP6 Protein Structure

U3_assoc_6

0
100
200
300
400
500
597 a.a.

Protein Preferred Names

Protein Names

U3 small nucleolar RNA-associated protein 6 homolog

UTP6, small subunit (SSU) processome component, homolog

UTP6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UTP6	Q9NYH9	APOE	Homo sapiens	P02649	Validated Y2H	32814053
Intra	UTP6	Q9NYH9	APOE	Homo sapiens	P02649	Y2H Array	32814053
Intra	UTP6	Q9NYH9	APOE	Homo sapiens	P02649	Y2H Pooling	32814053
Intra	UTP6	Q9NYH9	GBP1	Homo sapiens	P32455	Anti Tag CoIP	28514442
Intra	UTP6	Q9NYH9	GBP1	Homo sapiens	P32455	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 17q11.2 Deletion Syndrome

Nf1 Microdeletion Syndrome	17q11 Microdeletion Syndrome
Neurofibromatosis Type 1 Microdeletion Syndrome	Van Asperen Syndrome
Del(17)(Q11)	Monosomy 17q11
Chromosome 17q11.2 Deletion Syndrome, 1.4mb

Interstitial Keratitis

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

Chromosome 15q26-Qter Deletion Syndrome

Drayer Syndrome	15q26 Deletion Syndrome
Distal 15q Deletion Syndrome	Distal Monosomy 15q
Telomeric 15q Deletion Syndrome	Monosomy 15q26

Congenital Syphilis

Syphilis, Congenital	Congenital Syphilis, Unspecified
Mtct Of Syphilis	Mother-To-Child Transmission Of Syphilis
Syphilis Congenital	Hereditary Syphilis
Heredosyphilis

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15581	UTP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UTP6	MGD	MGI:2445193
Canis familiaris	UTP6	VGNC	VGNC:48214
Rattus norvegicus	UTP6	RGD	RGD:1311017
Felis catus	UTP6	VGNC	VGNC:66908
Macaca mulatta	UTP6	VGNC	VGNC:79122
Bos taurus	UTP6	VGNC	VGNC:36748

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