SELENOS - selenoprotein S Gene

Homo sapiens

Also known as SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015

Gene ID: 55829 | Gene type: protein coding

About SELENOS

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:101,270,809-101,277,485 (from NCBI)

This gene has 8 transcripts (splice variants) and 105 orthologues. Ubiquitous expression in testis (RPKM 27.4), colon (RPKM 26.5) and 25 other tissues.

Summary

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]

SELENOS Products(2)

mRNA	Protein	Name
NM_018445.6	NP_060915.2	selenoprotein S isoform 1
NM_203472.3	NP_982298.2	selenoprotein S isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	24424410	GOA
enables antioxidant activity	IDA IDA: Inferred from direct assay	15063746	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	15215856	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15215856	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	17000876	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ER overload response	IDA IDA: Inferred from direct assay	16574427	GOA
involved in ER overload response	IMP IMP: Inferred from mutant phenotype	17210132	GOA
involved in ERAD pathway	IDA IDA: Inferred from direct assay	15215856	GOA
involved in cell redox homeostasis	IDA IDA: Inferred from direct assay	15063746	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	18675776	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	18675776	GOA
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	15215856	GOA
involved in negative regulation of acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	18675776	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17210132	GOA
involved in negative regulation of macrophage apoptotic process	IMP IMP: Inferred from mutant phenotype	17210132	GOA
involved in negative regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	18675776	GOA
involved in regulation of nitric oxide metabolic process	IMP IMP: Inferred from mutant phenotype	18675776	GOA
involved in response to glucose	IEP IEP: Inferred from expression pattern	12031974	GOA
involved in response to redox state	IDA IDA: Inferred from direct assay	15063746	GOA
involved in retrograde protein transport, ER to cytosol	IDA IDA: Inferred from direct assay	15215856	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Derlin-1 retrotranslocation complex	IDA IDA: Inferred from direct assay	15215856	GOA
part of Derlin-1-VIMP complex	IDA IDA: Inferred from direct assay	15215856	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	23264731	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15215856	GOA
part of low-density lipoprotein particle	IDA IDA: Inferred from direct assay	17374524	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	17374524	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOS Protein Structure

Selenoprotein_S

0
100
189 a.a.

Protein Preferred Names

Protein Names

selenoprotein S

VCP interacting membrane selenoprotein

SELENOS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	SELENOS	Q9BQE4	P0DTD1-PRO_0000449625	SARS-CoV-2	P0DTD1-PRO_0000449625	Y2H Array	36217030
Intra	SELENOS	Q9BQE4	APOA5	Homo sapiens	Q6Q788	Y2H Prey Pooling	32296183
Intra	SELENOS	Q9BQE4	APOA5	Homo sapiens	Q6Q788	Y2H Array	32296183
Cross	SELENOS	Q9BQE4	Vcp	Mus musculus	Q01853	Anti Tag CoIP	15215856
Cross	SELENOS	Q9BQE4	Vcp	Mus musculus	Q01853	Anti Bait CoIP	15215856

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Esophageal Lipoma

Lipoma Of Esophagus

Dystonia 11, Myoclonic

Myoclonic Dystonia	Myoclonus-Dystonia Syndrome
DYT11	Myoclonic Dystonia 11
Alcohol-Responsive Dystonia	Myoclonus, Hereditary Essential
Dystonia-11, Myoclonic	Myoclonus-Dystonia
Dystonia 11	Hereditary Essential Myoclonus
Dystonia, Alcohol-Responsive	Dyt-Sgce
Dystonia, Alcohol Responsive	Dystonia-11
Dystonia, Myoclonic	Dystonia, Myoclonic, Type 11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12642	SELENOS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SELENOS	VGNC	VGNC:45983
Macaca mulatta	SELENOS	VGNC	VGNC:77344
Felis catus	SELENOS	VGNC	VGNC:64982
Rattus norvegicus	SELENOS	RGD	RGD:628897
Bos taurus	SELENOS	VGNC	VGNC:57162
Mus musculus	SELENOS	MGD	MGI:95994

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