LMO3 - LIM domain only 3 Gene

Homo sapiens

Also known as RBTN3; RHOM3; RBTNL2; Rhom-3

Gene ID: 55885 | Gene type: protein coding

About LMO3

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:16,548,372-16,610,174 (from NCBI)

This gene has 34 transcripts (splice variants), 205 orthologues and 20 paralogues. Biased expression in brain (RPKM 41.7), lung (RPKM 13.9) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

LMO3 Products(7)

mRNA	Protein	Name
NM_001001395.2	NP_001001395.1	LIM domain only protein 3 isoform 1
NM_001243609.1	NP_001230538.1	LIM domain only protein 3 isoform 1
NM_001243610.1	NP_001230539.1	LIM domain only protein 3 isoform 1
NM_001243611.1	NP_001230540.1	LIM domain only protein 3 isoform 2
NM_001243612.1	NP_001230541.1	LIM domain only protein 3 isoform 3
NM_001243613.1	NP_001230542.1	LIM domain only protein 3 isoform 4
NM_018640.5	NP_061110.2	LIM domain only protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	23823477	GOA
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23823477	GOA
involved in positive regulation of glucocorticoid receptor signaling pathway	IDA IDA: Inferred from direct assay	23823477	GOA
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	23823477	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23823477	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMO3 Protein Structure

LIM

0
100
145 a.a.

Protein Preferred Names

Protein Names

LIM domain only protein 3

LIM domain only 3 (rhombotin-like 2)

Related Diseases

Diseases

Alias

Chief Cell Adenoma

Chief Cell Adenoma Of Parathyroid Gland

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07719	LMO3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LMO3	MGD	MGI:102810
Bos taurus	LMO3	VGNC	VGNC:30935
Macaca mulatta	LMO3	VGNC	VGNC:100072
Felis catus	LMO3	VGNC	VGNC:68071
Canis familiaris	LMO3	VGNC	VGNC:42723
Rattus norvegicus	LMO3	RGD	RGD:1561357

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