SP4 - Sp4 transcription factor Gene

Homo sapiens

Also known as HF1B; SPR-1

Gene ID: 6671 | Gene type: protein coding

About SP4

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:21,428,083-21,514,822 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 3.6), thyroid (RPKM 3.0) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor that can bind to the GC promoter region of a variety of genes, including those of the photoreceptor signal transduction system. The encoded protein binds to the same sites in promoter CpG islands as does the transcription factor SP1, although its expression is much more restricted compared to that of SP1. This gene may be involved in bipolar disorder and schizophrenia. [provided by RefSeq, May 2016]

SP4 Products(3)

mRNA	Protein	Name
NM_001326542.2	NP_001313471.1	transcription factor Sp4 isoform 2
NM_001326543.2	NP_001313472.1	transcription factor Sp4 isoform 3
NM_003112.5	NP_003103.2	transcription factor Sp4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23332764	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within positive effect regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7559627	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12560508	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP4 Protein Structure

zf-H2C2_2

0
200
400
600
784 a.a.

Protein Preferred Names

Protein Names

transcription factor Sp4

Related Diseases

Diseases

Alias

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Spastic Paraplegia 5a, Autosomal Recessive

SPG5A	Hereditary Spastic Paraplegia 5a
Autosomal Recessive Spastic Paraplegia 5a	Autosomal Recessive Spastic Paraplegia Type 5a
Spastic Paraplegia 5a	Spastic Paraplegia Type 5a
Spastic Paraplegia Type 5a, Recessive	Autosomal Recessive Spastic Paraplegia
Spastic Paraplegia-5a	Paraplegia, Spastic, Autosomal Recessive, Type 5a

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156276	SP4e	Activator	/	Unkown
HY-156277	SP4f	Activator	/	Unkown
HY-RS13607	SP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SP4	VGNC	VGNC:80723
Macaca mulatta	SP4	VGNC	VGNC:77847
Bos taurus	SP4	VGNC	VGNC:35155
Rattus norvegicus	SP4	RGD	RGD:3741
Mus musculus	SP4	MGD	MGI:107595
Canis familiaris	SP4	VGNC	VGNC:46687
Others	SP4	NCBI

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