2. Gene
  3. TAX1BP1 - Tax1 binding protein 1 Gene

TAX1BP1 - Tax1 binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as T6BP; TXBP151; CALCOCO3

Gene ID: 8887 | Gene type: protein coding

About TAX1BP1

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,739,373-27,829,767 (from NCBI)

This gene has 13 transcripts (splice variants), 290 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 48.4), thyroid (RPKM 48.2) and 25 other tissues.

Summary

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced Apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with Apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

TAX1BP1 Products(6)

mRNA Protein Name
NM_001079864.3 NP_001073333.1 tax1-binding protein 1 isoform 2
NM_001206901.1 NP_001193830.1 tax1-binding protein 1 isoform 2
NM_001206902.2 NP_001193831.1 tax1-binding protein 1 isoform 3
NM_001362794.2 NP_001349723.1 tax1-binding protein 1 isoform 4
NM_001362795.2 NP_001349724.1 tax1-binding protein 1 isoform 5
NM_006024.7 NP_006015.4 tax1-binding protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10920205 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
27736772 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
27736772 GOA
involved in negative regulation of toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
28898289 GOA
involved in protein localization to phagocytic vesicle IDA
IDA: Inferred from direct assay
28898289 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
27736772 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAX1BP1 Protein Structure

CALCOCO1

CALCOCO1: Calcium binding and coiled-coil domain (CALCOCO1) like (16 - 469)

  • 0
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  • 600
  • 789 a.a.
Protein Preferred Names Protein Names

tax1-binding protein 1

TRAF6-binding protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14227 TAX1BP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TAX1BP1 VGNC VGNC:47125
Felis catus TAX1BP1 VGNC VGNC:102711
Mus musculus TAX1BP1 MGD MGI:1289308
Macaca mulatta TAX1BP1 VGNC VGNC:78101
Bos taurus TAX1BP1 VGNC VGNC:35619
Rattus norvegicus TAX1BP1 RGD RGD:708579