2. Gene
  3. TAX1BP1 - Tax1 binding protein 1 Gene

TAX1BP1 - Tax1 binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as T6BP; TXBP151; CALCOCO3

Gene ID: 8887 | Gene type: protein coding

About TAX1BP1

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,739,373-27,829,767 (from NCBI)

This gene has 13 transcripts (splice variants), 290 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 48.4), thyroid (RPKM 48.2) and 25 other tissues.

Summary

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced Apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with Apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

TAX1BP1 Products(6)

mRNA Protein Name
NM_001079864.3 NP_001073333.1 tax1-binding protein 1 isoform 2
NM_001206901.1 NP_001193830.1 tax1-binding protein 1 isoform 2
NM_001206902.2 NP_001193831.1 tax1-binding protein 1 isoform 3
NM_001362794.2 NP_001349723.1 tax1-binding protein 1 isoform 4
NM_001362795.2 NP_001349724.1 tax1-binding protein 1 isoform 5
NM_006024.7 NP_006015.4 tax1-binding protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10920205 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
27736772 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
27736772 GOA
involved in negative regulation of toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
28898289 GOA
involved in protein localization to phagocytic vesicle IDA
IDA: Inferred from direct assay
28898289 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
27736772 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAX1BP1 Protein Structure

CALCOCO1

CALCOCO1: Calcium binding and coiled-coil domain (CALCOCO1) like (16 - 469)

  • 0
  • 200
  • 400
  • 600
  • 789 a.a.
Protein Preferred Names Protein Names

tax1-binding protein 1

TRAF6-binding protein

TAX1BP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TAX1BP1 Q86VP1 PLEKHN1 Homo sapiens Q494U1
Y2H Array
31515488
Intra
TAX1BP1 Q86VP1 PLEKHN1 Homo sapiens Q494U1
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 NMRK1 Homo sapiens Q9NWW6
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 NMRK1 Homo sapiens Q9NWW6
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 NMRK1 Homo sapiens Q9NWW6
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 TBC1D15 Homo sapiens Q8TC07
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 EMILIN1 Homo sapiens Q9Y6C2-2
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 TCAF1 Homo sapiens Q9Y4C2-2
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 FAM168A Homo sapiens Q92567-2
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 TRIM45 Homo sapiens Q9H8W5-2
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 CXXC1 Homo sapiens Q9P0U4-2
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 SSX2 Homo sapiens Q16385
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 SSX2 Homo sapiens Q16385
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 RAD18 Homo sapiens Q9NS91
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 RAD18 Homo sapiens Q9NS91
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 TNIP3 Homo sapiens Q96KP6
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 TNIP3 Homo sapiens Q96KP6
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 TNIP3 Homo sapiens Q96KP6
Y2H Array
31515488
Intra
TAX1BP1 Q86VP1 MRPL53 Homo sapiens Q96EL3
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 MRPL53 Homo sapiens Q96EL3
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 MRPL53 Homo sapiens Q96EL3
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 TSEN2 Homo sapiens Q8NCE0
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 MAP1LC3C Homo sapiens Q9BXW4
Y2H Array
32296183
Intra
TAX1BP1 Q86VP1 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 UBC Homo sapiens P0CG48
Pull Down
18239685
Intra
TAX1BP1 Q86VP1 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 TNIP1 Homo sapiens Q15025
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
18239685
Intra
TAX1BP1 Q86VP1 TRAF6 Homo sapiens Q9Y4K3
Y2H
21988832
Intra
TAX1BP1 Q86VP1 TRAF6 Homo sapiens Q9Y4K3
Y2H
10920205
Intra
TAX1BP1 Q86VP1 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
10920205
Intra
TAX1BP1 Q86VP1 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 PLEKHB2 Homo sapiens Q96CS7
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 COG7 Homo sapiens P83436
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 COG7 Homo sapiens P83436
Y2H Array
31515488
Intra
TAX1BP1 Q86VP1 COG7 Homo sapiens P83436
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 FOXC2 Homo sapiens Q99958
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 FOXC2 Homo sapiens Q99958
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 CWF19L2 Homo sapiens Q2TBE0
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 MRPL11 Homo sapiens Q9Y3B7
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 MRPL11 Homo sapiens Q9Y3B7
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 TCEA2 Homo sapiens Q15560
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 TCEA2 Homo sapiens Q15560
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 L3MBTL2 Homo sapiens Q969R5
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 LGALS8 Homo sapiens O00214
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 LGALS8 Homo sapiens O00214
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 LGALS8 Homo sapiens O00214
Y2H Array
29892012
Intra
TAX1BP1 Q86VP1 ZNF446 Homo sapiens Q9NWS9-2
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 ARK2N Homo sapiens Q96B23
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 LMO3 Homo sapiens Q8TAP4
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 EMILIN1 Homo sapiens Q9Y6C2
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 EMILIN1 Homo sapiens Q9Y6C2
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 DSTN Homo sapiens P60981
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 q8wu02_human Homo sapiens Q8WU02
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 GRN Homo sapiens P28799
Y2H Array
32814053
Intra
TAX1BP1 Q86VP1 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
TAX1BP1 Q86VP1 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
TAX1BP1 Q86VP1 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 RALBP1 Homo sapiens Q15311
Anti Tag CoIP
18239685
Intra
TAX1BP1 Q86VP1 RALBP1 Homo sapiens Q15311
Anti Tag CoIP
17703191
Intra
TAX1BP1 Q86VP1 FAM168A Homo sapiens Q92567
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 FAM168A Homo sapiens Q92567
Y2H Prey Pooling
25416956
Intra
TAX1BP1 Q86VP1 CHUK Homo sapiens O15111
Anti Bait CoIP
21765415
Intra
TAX1BP1 Q86VP1 CHUK Homo sapiens O15111
Protein Kinase Assay
21765415
Intra
TAX1BP1 Q86VP1 TSHZ3 Homo sapiens Q63HK5
Validated Y2H
25416956
Intra
TAX1BP1 Q86VP1 TSHZ3 Homo sapiens Q63HK5
Y2H Array
25416956
Intra
TAX1BP1 Q86VP1 LRATD2 Homo sapiens Q96KN1
Validated Y2H
32296183
Intra
TAX1BP1 Q86VP1 CXXC1 Homo sapiens Q9P0U4
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14227 TAX1BP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TAX1BP1 VGNC VGNC:47125
Felis catus TAX1BP1 VGNC VGNC:102711
Mus musculus TAX1BP1 MGD MGI:1289308
Macaca mulatta TAX1BP1 VGNC VGNC:78101
Bos taurus TAX1BP1 VGNC VGNC:35619
Rattus norvegicus TAX1BP1 RGD RGD:708579