MAPK6 - mitogen-activated protein kinase 6 Gene

Homo sapiens

Also known as ERK3; PRKM6; p97MAPK; HsT17250

Gene ID: 5597 | Gene type: protein coding

About MAPK6

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:51,971,825-52,067,375 (from NCBI)

This gene has 13 transcripts (splice variants), 229 orthologues and 19 paralogues. Ubiquitous expression in testis (RPKM 25.2), brain (RPKM 20.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

MAPK6 Products(1)

mRNA	Protein	Name
NM_002748.4	NP_002739.1	mitogen-activated protein kinase 6

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK6 Protein Structure

Pkinase

0
200
400
600
721 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase 6

ERK-3

MAPK6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAPK6	Q16659	EGLN3	Homo sapiens	Q9H6Z9	Anti Tag CoIP	26972000
Intra	MAPK6	Q16659	EGLN3	Homo sapiens	Q9H6Z9	Anti Bait CoIP	26972000
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41-2	Anti Tag CoIP	28514442
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41-2	Anti Tag CoIP	29426014
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41-2	Validated Y2H	32296183
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41	Y2H Prey Pooling	25416956
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41	Anti Tag CoIP	33961781
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41	TAP	23602568
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41	Anti Tag CoIP	26972000
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41	Y2H Array	25416956
Intra	MAPK6	Q16659	MAPKAPK5	Homo sapiens	Q8IW41	Pull Down	32707033
Intra	MAPK6	Q16659	ANKRD2	Homo sapiens	Q9GZV1	Validated Y2H	32296183
Intra	MAPK6	Q16659	APOA1	Homo sapiens	P02647	Anti Tag CoIP	33961781
Intra	MAPK6	Q16659	APOA1	Homo sapiens	P02647	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pulmonary Immaturity

Primary Atelectasis Of Newborn	Primary Atelectasis, In Perinatal Period
Primary Failure To Expand Terminal Respiratory Units	Immature Lungs
Primary Atelectasis	Pulmonary Immaturity Nos
Lung Lobe Hypoplasia, Associated With Short Gestation	Lung Nonexpansion
Premature Lungs	Pulmonary Hypoplasia Associated With Short Gestation
Failure Of Expansion Of Terminal Respiratory Units	Primary Atelectasis Of Fetus Or Newborn
Primary Atelectasis In Perinatal Period

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1568A	Flagelin 22 TFA	Agonist	97.00%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-P1568	Flagelin 22	Agonist	/	Unkown
HY-RS08117	MAPK6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAPK6	VGNC	VGNC:42999
Bos taurus	MAPK6	VGNC	VGNC:31221
Felis catus	MAPK6	VGNC	VGNC:68170
Mus musculus	MAPK6	MGD	MGI:1354946
Rattus norvegicus	MAPK6	RGD	RGD:62087
Others	MAPK6	NCBI

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