ACRV1 - acrosomal vesicle protein 1 Gene

Homo sapiens

Also known as SP-10; SPACA2; D11S4365

Gene ID: 56 | Gene type: protein coding

About ACRV1

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,671,522-125,680,847 (from NCBI)

This gene has 4 transcripts (splice variants), 91 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 39.8).

Summary

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

ACRV1 Products(4)

mRNA	Protein	Name
NM_001612.6	NP_001603.1	acrosomal protein SP-10 isoform a precursor
NM_020069.5	NP_064454.1	acrosomal protein SP-10 isoform b precursor
NM_020107.5	NP_064492.1	acrosomal protein SP-10 isoform c precursor
NM_020108.5	NP_064493.1	acrosomal protein SP-10 isoform d precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acrosomal protein SP-10

sperm protein 10

ACRV1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ACRV1	P26436	CISD2	Homo sapiens	Q8N5K1	Y2H Pooling	32814053
Intra	ACRV1	P26436	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32814053
Intra	ACRV1	P26436	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32814053
Intra	ACRV1	P26436	PPT1	Homo sapiens	P50897	Validated Y2H	32814053
Intra	ACRV1	P26436	PPT1	Homo sapiens	P50897	Y2H Array	32814053
Intra	ACRV1	P26436	PPT1	Homo sapiens	P50897	Y2H Pooling	32814053
Intra	ACRV1	P26436	PANK2	Homo sapiens	Q9BZ23-2	Y2H Pooling	32814053
Intra	ACRV1	P26436	PANK2	Homo sapiens	Q9BZ23-2	Validated Y2H	32814053
Intra	ACRV1	P26436	PANK2	Homo sapiens	Q9BZ23-2	Y2H Array	32814053
Intra	ACRV1	P26436	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ACRV1	P26436	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ACRV1	P26436	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ACRV1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71139	SP-10/ACRV1 Protein, Human (HEK293, C-His)	P26436-1 (Q22-I265)	≥95%

Related Diseases

Diseases

Alias

Byssinosis

Flax-Dressers' Disease	Cotton Mill Fever
Stripper'S Asthma	Monday Morning Fever
Cotton Workers' Lung Disease	Cotton-Dust Asthma
Mill Fever	Lung Fibrosis With Byssinosis
Airway Disease Due To Cotton Dust	Respiratory Tract Disorder Due To Cotton Dust
Strippers' Disease	Flax-Dressers' Disorder
Strippers' Asthma

Hordeolum

Stye	Boil Of Eyelid
Furuncle Of Eyelid	Hordeolum Externum

Spastic Hemiplegia

Spastic Hemiplegic Cerebral Palsy	Hemiplegic Cerebral Palsy
Congenital Hemiplegia	Hemiplegic Infantile Cerebral Palsy
Cerebral Palsy Spastic Hemiplegic	Spastic Hemiplegia Cerebral Palsy
Hemiplegia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00195	ACRV1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ACRV1	VGNC	VGNC:37528
Bos taurus	ACRV1	VGNC	VGNC:25559
Rattus norvegicus	ACRV1	RGD	RGD:620153
Mus musculus	ACRV1	MGD	MGI:104590
Macaca mulatta	ACRV1	VGNC	VGNC:99536
Others	ACRV1	NCBI

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